ReviewJournal of fungi (Basel, Switzerland)2022
Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review.
Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Association of meteorological factors with allergic rhinitis: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Enhancing Lactate Assimilation inJournal of fungi (Basel, Switzerland) · 2026Article
- A Novel Chymotrypsin-like Protease fromFoods (Basel, Switzerland) · 2026Article
- From the bench to the reactor: engineered filamentous fungi for biochemical and biomaterial production.Biotechnology for biofuels and bioproducts · 2025Review
- Recombinant Proteins: Evolution to their Therapeutic Potential.Protein and peptide letters · 2025Review
- Selective Hydrolysis of Heterooligosaccharides by Poly(acrylate) Gel Catalysts.ACS catalysis · 2024Article
- Support Enzyme Loading Influences the Effect of Aldehyde Dextran Modification on the Specificity of Immobilized Ficin for Large Proteins.Molecules (Basel, Switzerland) · 2024Article
- First Insight into the Degradome ofInternational journal of molecular sciences · 2024Article
- Article
- Impact of climate change on paediatric respiratory health: pollutants and aeroallergens.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases.The Journal of allergy and clinical immunology · 2023Review
- Extracellular proteases from halophiles: diversity and application challenges.Applied microbiology and biotechnology · 2023Review
- Hemostatically Active Proteinase Produced byInternational journal of molecular sciences · 2023Article
- Fungal Biotechnology and Applications.Journal of fungi (Basel, Switzerland) · 2023Article
- Effects of the Exopolysaccharide fromFoods (Basel, Switzerland) · 2023Article
- Fungal alkaline proteases and their potential applications in different industries.Frontiers in microbiology · 2023Review
- Heterologous Expression of Extracellular Proteinase pAsPs ofInternational journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increasing world population, demand for industrialization has also increased to fulfill humans' living standards. Fungi are considered a source of essential constituents to produce the biocatalytic enzymes, including amylases, proteases, lipases, and cellulases that contain broad-spectrum industrial and emerging applications. The present review discussed the origin, nature, mechanism of action, emerging aspects of genetic engineering for designing novel proteases, genome editing of fungal strains through CRISPR technology, present challenges and future recommendations of fungal proteases. The emerging evidence revealed that fungal proteases show a protective role to many environmental exposures and discovered that an imbalance of protease inhibitors and proteases in the epithelial barriers leads to the protection of chronic eosinophilic airway inflammation. Moreover, mitoproteases recently were found to execute intense proteolytic processes that are crucial for mitochondrial integrity and homeostasis function, including mitochondrial biogenesis, protein synthesis, and apoptosis. The emerging evidence revealed that CRISPR/Cas9 technology had been successfully developed in various filamentous fungi and higher fungi for editing of specific genes. In addition to medical importance, fungal proteases are extensively used in different industries such as foods to prepare butter, fruits, juices, and cheese, and to increase their shelf life. It is concluded that hydrolysis of proteins in industries is one of the most significant applications of fungal enzymes that led to massive usage of proteomics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.