SynthesisInternational journal of environmental research and public health2022
Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The Role of Selenium During Gestation in the Development of Fetal Congenital Anomalies: A Systematic Review.Nutrients · 2026Pooled it
- Clinical characteristics, management, and outcomes of diseases caused by mercury overexposure: a systematic review of case reports and case series.Frontiers in public health · 2026Pooled it
- Human Mercury Biomonitoring Under the Minamata Convention: Blood, Urine, Hair, and Tissue Biomarkers (2000-2026).Biological trace element research · 2026Review
- Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction.The FEBS journal · 2026Review
- Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Mercury in southern legal Amazonia: evaluating Prochilodus nigricans (Agassiz, 1829) as a bioindicator species and the risk of its consumption.Environmental monitoring and assessment · 2026Article
- Activation of anti-inflammatory pathways by polyunsaturated fatty acid signaling may protect neurodevelopment in children prenatally exposed to methylmercury.Environmental health : a global access science source · 2026Article
- Rice bran extract ameliorates metal mixture induced cerebral cortex dysfunction: implicating the Nrf-2/HMOX-1/BDNF signalling pathway.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Metal Pollution in the Air and Its Effects on Vulnerable Populations: A Narrative Review.International journal of molecular sciences · 2026Review
- Seafood consumption patterns and methylmercury risk awareness among Saudi adults: a nationwide cross-sectional survey documenting a structural knowledge-behavior gap.Frontiers in public health · 2026Article
- Through the Eye: Retinal Changes of Prenatal Mercury Exposure in Grassy Narrows First Nation, Canada.International journal of environmental research and public health · 2025Article
- Article
- Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke.Antioxidants (Basel, Switzerland) · 2025Review
- Bioaccumulation of Trace Elements in Fish From Lake Kivu and Its Potential Risk to Consumers in Rwanda.Food science & nutrition · 2025Article
- Environmental adversity, endoplasmic reticulum stress, and neurogenesis.Neurotoxicology · 2025Review
- Sediment mercury and methylmercury dynamics during reservoir operation.Scientific reports · 2025Article
- Seafood intake in children at age 7 years and neurodevelopmental outcomes in an observational cohort study (ALSPAC).European journal of nutrition · 2025Observational
- Mercury Levels in Hair of Pregnant Women in Tumbes, Peru: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2025Article
- Munduruku Indigenous children: health situation in an area with high mercury exposure.Revista de saude publica · 2025Article
- Molecular signature of cadmium-mediated neurodevelopmental disorders in prenatal to postnatal stages.EXCLI journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurodevelopmental delays can interfere with children's engagement with the world and further development, and may have negative consequences into adulthood. Mercury is highly toxic and may negatively influence neurodevelopment because it can freely cross the placenta and accumulate in the fetal brain. We searched four publication databases (Embase, PsycINFO, PubMed/MEDLINE, Scopus) for studies examining the relationship between early life mercury exposure and scores on neurodevelopmental performance measures in children aged 0 to 5 years old. Study quality was assessed using the National Institutes of Health (NIH) Quality Assessment Tool. Thirty-two prospective studies were included in the review. Neurodevelopmental performance was measured using 23 different scales, most commonly the Bayley Scales of Infant and Toddler Development (BSID). In most cases, the evidence for an association between mercury and neurodevelopment was weak. There did not appear to be exceptions for particular childhood ages, outcome scales, or mercury levels. The small number of results to the contrary were more likely to be studies which did not meet our high-quality criteria, and could be a consequence of multiple testing, selection bias, or incomplete confounder adjustment. Based on current evidence, dietary mercury exposure during pregnancy is unlikely to be a risk factor for low neurodevelopmental functioning in early childhood.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.