Evidence map›Paper›PMID 35207566›Full record

ReviewLife (Basel, Switzerland)2022

Artificial Intelligence and Cardiovascular Genetics.

Chayakrit Krittanawong, Kipp W Johnson, Edward Choi, Scott Kaplin, Eric Venner, Mullai Murugan, Zhen Wang, Benjamin S Glicksberg, Christopher I Amos, Michael C Schatz and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Chayakrit KrittanawongSection of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA.
Kipp W JohnsonThe Hasso Plattner Institute for Digital Health at the Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-5102-741X
Edward ChoiGoogle Health Research, Google, Mountain View, CA 94043, USA.
Scott KaplinDepartment of Cardiovascular Medicine, NYU Langone, New York, NY 10016, USA.ORCID 0000-0002-9464-0062
Eric VennerHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3319-6690
Mullai MuruganHuman Genome Sequencing Center, Department of Software Development, Baylor College of Medicine, Houston, TX 77030, USA.
Zhen WangRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN 55905, USA.
Benjamin S GlicksbergThe Hasso Plattner Institute for Digital Health at the Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4515-8090
Christopher I AmosDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8540-7023
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-4118-4446
W H Wilson TangDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-8335-735X
Baylor College of Medicine · USIcahn School of Medicine at Mount Sinai · USCleveland Clinic · USGoogle (United States) · USJohns Hopkins University · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polygenic diseases, which are genetic disorders caused by the combined action of multiple genes, pose unique and significant challenges for the diagnosis and management of affected patients. A major goal of cardiovascular medicine has been to understand how genetic variation leads to the clinical heterogeneity seen in polygenic cardiovascular diseases (CVDs). Recent advances and emerging technologies in artificial intelligence (AI), coupled with the ever-increasing availability of next generation sequencing (NGS) technologies, now provide researchers with unprecedented possibilities for dynamic and complex biological genomic analyses. Combining these technologies may lead to a deeper understanding of heterogeneous polygenic CVDs, better prognostic guidance, and, ultimately, greater personalized medicine. Advances will likely be achieved through increasingly frequent and robust genomic characterization of patients, as well the integration of genomic data with other clinical data, such as cardiac imaging, coronary angiography, and clinical biomarkers. This review discusses the current opportunities and limitations of genomics; provides a brief overview of AI; and identifies the current applications, limitations, and future directions of AI in genomics.

Indexed as

AIartificial intelligencecardiologycardiovascular diseasedeep learninggeneticsgenomicsmachine learning

Identifiers

PMID35207566
PMCPMC8875522
OpenAlexW4212791668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.