Evidence map›Paper›PMID 35207633›Full record

ArticleJournal of personalized medicine2022

The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome.

Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R Starkweather, Erin E Young, Xiaomei Cong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tingting ZhaoSchool of Nursing, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-2856-1048
Yiming ZhangDepartment of Statistics, University of Connecticut, Storrs, CT 06269, USA.
Joochul LeeDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Angela R StarkweatherSchool of Nursing, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0001-7168-0144
Erin E YoungDepartment of Anesthesiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Xiaomei CongSchool of Nursing, University of Connecticut, Storrs, CT 06269, USA.

Funding

National Institute of Health P20NR016605National Institute of Health R01NR016928
6 · The paper itself

Abstract

Although several risk single nucleotide polymorphisms (SNPs) have been found to play an important role in etiology of irritable bowel syndrome (IBS), the findings are inconsistent. A descriptive correlational design was used to analyze the baseline data of a randomized controlled trial including participants with IBS and healthy controls (HC). Pain severity and interference, anxiety, sleep, and fatigue were measured using the Brief Pain Inventory (BPI) and patient-reported outcomes measurement information system (PROMIS). Fisher's exact test and multivariate linear regression were used to investigate the associations between IBS risk alleles and IBS symptoms. Participants were predominantly female, white, and had an average age of 21.13 ± 2.42 years. Polymorphisms within

Indexed as

fatigueirritable bowel syndromepain interferencesingle nucleotide polymorphismssleep disturbance

Identifiers

PMID35207633
PMCPMC8878682

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.