ArticleJournal of personalized medicine2022
Differences and Commonalities in Children with Childhood Apraxia of Speech and Comorbid Neurodevelopmental Disorders: A Multidimensional Perspective.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Deciphering the genetic basis of developmental language disorder in children without intellectual disability, autism or apraxia of speech.Molecular autism · 2025Trial
- Multidomain Developmental Indicators in 4- to 9-Year-Old Children with Oral Motor and Speech Sound Disorders.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2026Article
- Atypical GNAO1 variants in severe childhood speech disorders: clinical, genetic, and molecular insights.Molecular autism · 2025Article
- Examining Transdiagnostic Patterns of Motor Differences: Preliminary Findings From the Consortium for Motor Behavior in Neurodivergence (COMBINE).Journal of autism and developmental disorders · 2025Article
- A Novel Candidate Neuromarker of Central Motor Dysfunction in Childhood Apraxia of Speech.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurolinguistic and acoustic analysis of articulatory impairments in Arabic speech disorders.Frontiers in human neuroscience · 2025Article
- Alterations of the neural substrate in childhood apraxia of speech: new evidence from neuroimaging.Brain communications · 2025Article
- Importance of copy number variants in childhood apraxia of speech and other speech sound disorders.Communications biology · 2024Article
- Childhood Apraxia of Speech: A Descriptive and Prescriptive Model of Assessment and Diagnosis.Brain sciences · 2024Article
- Expanding the molecular landscape of childhood apraxia of speech: evidence from a single-center experience.Frontiers in neuroscience · 2024Article
- Relationship among Connectivity of the Frontal Aslant Tract, Executive Functions, and Speech and Language Impairment in Children with Childhood Apraxia of Speech.Brain sciences · 2022Article
- PROMPT to improve speech motor abilities in children with cerebral palsy: a wait-list control group trial protocol.BMC neurology · 2022Article
- Speech and language therapists' insights into severity of speech sound disorders in children for developing the speech sound disorder severity construct.International journal of language & communication disordersArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Childhood apraxia of speech (CAS) is a motor speech disorder often co-occurring with language impairment and complex neurodevelopmental disorders. A cohort of 106 children with CAS associated to other neurodevelopmental disorders underwent a multidimensional investigation of speech and language profiles, chromosome microarray analysis and structural brain magnetic resonance (MR). Our aim was to compare the clinical profiles of children with CAS co-occurring with only language impairment with those who, in addition to language impairment, had other neurodevelopmental disorders. Expressive grammar was impaired in the majority of the sample in the context of similar alterations of speech, typical of the core symptoms of CAS. Moreover, children with complex comorbidities also showed more severe and persistent receptive language deficits. About 25% of the participants harbored copy number variations (CNVs) already described in association to neurodevelopmental disorders. CNVs occurred more frequently in children with complex comorbidities. MR structural/signal alterations were found in a small number of children and were of uncertain pathogenic significance. These results confirm that CAS needs multidimensional diagnostic and clinical management. The high frequency of language impairment has important implications for early care and demands a personalized treatment approach in which speech and language goals are consistently integrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.