Evidence map›Paper›PMID 35209228›Full record

ArticleMolecules (Basel, Switzerland)2022

Rationalisation of Antifungal Properties of α-Helical Pore-Forming Peptide, Mastoparan B.

Edward Jianyang Lim, Eunice Goh Tze Leng, Nhan Dai Thien Tram, Mercy Halleluyah Periayah, Pui Lai Rachel Ee, Timothy Mark Sebastian Barkham, Zhi Sheng Poh, Navin Kumar Verma, Rajamani Lakshminarayanan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025
    Article
  2. Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Identification and Characterization of an Antifungal GeneInternational journal of molecular sciences · 2023
    Article
  4. Eco-Friendly Synthesis of an Oxovanadium(IV)-Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Edward Jianyang LimOcular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.
Eunice Goh Tze LengOcular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.
Nhan Dai Thien TramDepartment of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
Mercy Halleluyah PeriayahOcular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.
Pui Lai Rachel EeDepartment of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
Timothy Mark Sebastian BarkhamDepartment of Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.ORCID 0000-0003-0975-2244
Zhi Sheng PohLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11 Mandalay Road, Singapore 308232, Singapore.
Navin Kumar VermaOcular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.ORCID 0000-0002-5940-6633
Rajamani LakshminarayananOcular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore.ORCID 0000-0001-8214-5315
National University of Singapore · SGSingapore Eye Research Institute · SGNanyang Technological University · SGNational Skin Centre · SGTan Tock Seng Hospital · SG

Funding

SingHealth Foundation SHF/FG663P/2017
6 · The paper itself

Abstract

The high mortality associated with invasive fungal infections, narrow spectrum of available antifungals, and increasing evolution of antifungal resistance necessitate the development of alternative therapies. Host defense peptides are regarded as the first line of defense against microbial invasion in both vertebrates and invertebrates. In this work, we investigated the effectiveness of four naturally occurring pore-forming antimicrobial peptides (melittin, magainin 2, cecropin A, and mastoparan B) against a panel of clinically relevant pathogens, including

Indexed as

Antifungal AgentsAntimicrobial Cationic PeptidesCell LineCell Line, TumorCell SurvivalChemical PhenomenaHumansIntercellular Signaling Peptides and ProteinsMicrobial Sensitivity TestsModels, MolecularProtein ConformationSpectrum AnalysisStructure-Activity RelationshipAntifungal AgentsAntimicrobial Cationic PeptidesIntercellular Signaling Peptides and Proteinsmastoparan Bantifungal peptidesdrug resistanceinvasive fungal infectionsnon-albicans Candidaskin wounds

Identifiers

PMID35209228
PMCPMC8879275
OpenAlexW4213085941

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.