ArticleHypertension research : official journal of the Japanese Society of Hypertension2022
Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Cognitive impairment and associated factors among community-dwelling older adults with hypertension in tropical China.Frontiers in public health · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Response to the letter regarding "Rethinking physical and cognitive frailty definitions in the JOINT-05 teriparatide sub-analysis".Journal of bone and mineral metabolism · 2026Article
- Hypertensive dementia and blood pressure management from JSH2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The mediating role of instrumental activities of daily living between cognitive function and depressive symptoms in community-dwelling older adults: the Arao study.BMC psychiatry · 2025Article
- Exploring the association between hemoglobin glycation index and cognitive function in older adults with hypertension: a cross-sectional study.BMC geriatrics · 2025Article
- Risk factors and traditional Chinese medicine syndromes of mild cognitive impairment in community-dwelling hypertensive older adults.Frontiers in public health · 2025Article
- 2023 update and perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- A risk prediction model based on machine learning for early cognitive impairment in hypertension: Development and validation study.Frontiers in public health · 2023Article
- Is unrecognized cognitive impairment in hypertension unmasked by diabetes mellitus?Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Preface-Special issue for hypertension in Asia: from the Okinawa declaration to the ISH 2022.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Association of Type D personality and mild cognitive impairment in patients with hypertension.Frontiers in psychology · 2022Article
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16 authors at 6 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To treat older patients with hypertension, it is important to detect cognitive impairment at an early stage because of its potential influence on treatment efficacy and functional prognosis. In this study, we aimed to identify the incidence and determinants of cognitive impairment in hypertensive patients aged 65 years and above who visited our outpatient clinic and were not previously diagnosed with cognitive impairment. Among 312 patients with hypertension, we found that 35% (n = 109) and 7.7% (n = 24) had cognitive impairment and dementia, respectively, as defined by the Mini-Mental State Examination (≤27 or ≤23, respectively). Patients with cognitive impairment were older, had lower levels of education, and had lower instrumental activities of daily living (IADL) scores than those without cognitive impairment. Multiple regression analysis revealed that age and IADL were associated with cognitive impairment in patients with hypertension. Regarding the treatment of hypertension, the office and home blood pressure levels, number of antihypertensive medications prescribed, and proportion of the use of each antihypertensive drug was equivalent between patients with and without cognitive impairment. Finally, patients with unrecognized cognitive impairment showed distinct clinical characteristics, including high antihypertensive medication burden and preserved IADL, when compared to hypertensive patients in the different cohorts of definitive mild cognitive impairment of a similar age. These findings suggest that older hypertensive patients are at a high risk of masked cognitive decline, even if they are functionally independent.
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