Evidence map›Paper›PMID 35211369›Full record

Article3 Biotech2022

Antioxidant-biocompatible and stable catalase-based gelatin-alginate hydrogel scaffold with thermal wound healing capability: immobilization and delivery approach.

Heidi Mohamed Abdel-Mageed, Amira Emad Abd El Aziz, Batoul Mohamed Abdel Raouf, Saleh Ahmed Mohamed, Dina Nada

Open access · hybridAbstract read
In one paragraph

Article in 3 Biotech, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Heidi Mohamed Abdel-MageedMolecular Biology Department, National Research Centre, El Behoth St, Dokki, Cairo, Egypt.ORCID 0000-0002-2944-1518
Amira Emad Abd El AzizCentre of Excellence, Arab Academy for Science and Technology and Maritime Transport, Alexandria, Egypt.
Batoul Mohamed Abdel RaoufPediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0000-0001-8116-7301
Saleh Ahmed MohamedMolecular Biology Department, National Research Centre, El Behoth St, Dokki, Cairo, Egypt.ORCID 0000-0003-2978-9466
Dina NadaPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt.
National Research Centre · EGAin Shams University · EGArab Academy for Science, Technology, and Maritime Transport · EGBritish University in Egypt · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogel-based matrix prepared using biopolymers is a new frontier of emerging platforms for enzyme immobilization for biomedical applications. Catalase (CAT) delivery can be effective in inhibiting reactive oxygen species (ROS)-mediated prolongation of the wound healing process. In this study, to improve CAT stability for effective application, gelatin(Gel)-alginate (Alg) biocompatible hydrogel (Gel-Alg), as immobilization support, was prepared using calcium chloride as an ionic cross-linker. High entrapment efficiency of 92% was obtained with 2% Gel and 1.5% Alg. Hydrogel immobilized CAT (CAT-Gel-Alg) showed a wide range of pH from 4 to 9 and temperature stability between 20 to 60 °C, compared to free CAT. CAT-Gel-Alg kinetic parameters revealed an increased

Indexed as

Burn wound healingCatalase immobilizationGelatin alginate biopolymersHalf-lifeHydrogelStabilizationThermal injury

Identifiers

PMID35211369
PMCPMC8859020
OpenAlexW4213274540

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.