Evidence map›Paper›PMID 35211821›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Correlation between olfactory function, age, sex, and cognitive reserve index in the Italian population.

Carla Masala, Annachiara Cavazzana, Fabrizio Sanna, Maria Paola Cecchini, Alice Zanini, Flavia Gasperi, Leonardo Menghi, Isabella Endrizzi, Monica Borgogno, Serena Drago and 20 more

Abstract read
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Assessment and behavioural management options for older adults with declined smell and taste functions: a scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Carla MasalaDepartment of Biomedical Sciences, University of Cagliari, SP8 Cittadella Universitaria Monserrato, 09042, Cagliari, Italy. cmasala@unica.it.ORCID http://orcid.org/0000-0001-5272-8421
Annachiara CavazzanaDepartment of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
Fabrizio SannaDepartment of Biomedical Sciences, University of Cagliari, SP8 Cittadella Universitaria Monserrato, 09042, Cagliari, Italy.
Maria Paola CecchiniSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Alice ZaniniSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Flavia GasperiResearch and Innovation Centre, Fondazione Edmund Mach, Via E. Mach, 1, San Michele All'Adige, 38010, Trento, Italy.
Leonardo MenghiResearch and Innovation Centre, Fondazione Edmund Mach, Via E. Mach, 1, San Michele All'Adige, 38010, Trento, Italy.
Isabella EndrizziResearch and Innovation Centre, Fondazione Edmund Mach, Via E. Mach, 1, San Michele All'Adige, 38010, Trento, Italy.
Monica BorgognoMérieux NutriSciences Italia, Prato, Italy.
Serena DragoMérieux NutriSciences Italia, Prato, Italy.
Elena CantoneNeurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, Federico II University, Naples, Italy.
Andrea CiofaloNeurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, Federico II University, Naples, Italy.
Alberto MacchiORL Clinica, University of Insubria and Varese, ASST Settelaghi, Varese, Italy.
Giulia MontiORL Clinica, University of Insubria and Varese, ASST Settelaghi, Varese, Italy.
Valentina ParmaMonell Chemical Senses Center, 3500 Market Street, Philadelphia, 19104, USA.
Maria PiochiUniversity of Gastronomic Sciences, Pollenzo, Cuneo, Italy.
Ilenia PinnaDepartment of Biomedical Sciences, University of Cagliari, SP8 Cittadella Universitaria Monserrato, 09042, Cagliari, Italy.
Luisa TorriUniversity of Gastronomic Sciences, Pollenzo, Cuneo, Italy.
Giorgia CabrinoUniversity of Gastronomic Sciences, Pollenzo, Cuneo, Italy.
Giancarlo OttavianoDepartment of Neuroscience, ENT Section, University of Padua, Padua, Italy.
Alfonso Luca PendolinoDepartment of Neuroscience, ENT Section, University of Padua, Padua, Italy.
Angela PignatelliDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Faride PighinDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Vincenzo BochicchioDepartment of Humanistic Studies, University of Calabria, Rende, Italy.
Gaetano MottaClinic of Otorhinolaryngology, Head and Neck Surgery Unit, Department of Anesthesiology, Surgical and Emergency Science, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giorgia FontanaGeriatric Unit A, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Benedetta PasquarielloUnit of Rhinology, Department of Organi di Senso, University La Sapienza, Rome, Italy.
Carlo CavaliereUnit of Rhinology, Department of Organi di Senso, University La Sapienza, Rome, Italy.
Valentina IaconoDivision of Nephrology and Dialysis, "Santa Maria della Misericordia" Hospital, Rovigo, Italy.
Thomas HummelDepartment of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLoss of smell decreases the quality of life and contributes to the failure in recognizing hazardous substances. Given the relevance of olfaction in daily life, it is important to recognize an undiagnosed olfactory dysfunction to prevent these possible complications. Up to now, the prevalence of smell disorders in Italy is unknown due to a lack of epidemiological studies. Hence, the primary aim of this study was to evaluate the prevalence of olfactory dysfunction in a sample of Italian adults.

methodsSix hundred and thirty-three participants (347 woman and 286 men; mean age 44.9 years, SD 17.3, age range 18-86) were recruited from 10 distinct Italian regions. Participants were recruited using a convenience sapling and were divided into six different age groups: 18-29 years (N = 157), 30-39 years (N = 129), 40-49 years (N = 99), 50-59 years (N = 106), > 60 years (N = 142). Olfactory function, cognitive abilities, cognitive reserve, and depression were assessed, respectively, with: Sniffin' Sticks 16-item Odor Identification Test, Montreal Cognitive Assessment, Cognitive Reserve Index, and the Beck Depression Inventory. Additionally, socio-demographic data, medical history, and health-related lifestyle information were collected.

resultsAbout 27% of participants showed an odor identification score < 12 indicating hyposmia. Multiple regression analysis revealed that OI was significantly correlated with age, sex, and cognitive reserve index, and young women with high cognitive reserve index showing the highest olfactory scores.

conclusionThis study provides data on the prevalence of olfactory dysfunction in different Italian regions.

Indexed as

Cognitive ReserveOlfaction DisordersAdolescentAdultAgedAged, 80 and overFemaleHumansItalyMaleMiddle AgedOdorantsQuality of LifeSmellYoung AdultChemosensory systemIdentificationOlfactionOlfactory functionSmellSniffin’ Sticks

Identifiers

PMID35211821
PMCPMC8869341

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.