Evidence map›Paper›PMID 35212809›Full record

ArticleCellular and molecular life sciences : CMLS2022

CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity.

Karolina Losenkova, Akira Takeda, Symantas Ragauskas, Marc Cerrada-Gimenez, Maria Vähätupa, Simon Kaja, Marius L Paul, Constanze C Schmies, Georg Rolshoven, Christa E Müller and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Microglial polarization in retinal neovascularization: Friend or foe?Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Karolina LosenkovaMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Akira TakedaMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Symantas RagauskasExperimentica UAB, Vilnius, Lithuania.
Marc Cerrada-GimenezExperimentica Ltd., Kuopio, Finland.
Maria VähätupaExperimentica Ltd., Kuopio, Finland.
Simon KajaExperimentica Ltd., Kuopio, Finland.
Marius L PaulMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Constanze C SchmiesPharma Center Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany.
Georg RolshovenPharma Center Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany.
Christa E MüllerPharma Center Bonn, Pharmaceutical Institute, Pharmaceutical and Medicinal Chemistry, University of Bonn, Bonn, Germany.
Jouko SandholmTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Giedrius KalesnykasExperimentica UAB, Vilnius, Lithuania.
Gennady G YegutkinMediCity Research Laboratory and InFLAMES Flagship, University of Turku, Tykistökatu 6A, 20520, Turku, Finland. gennady.yegutkin@utu.fi.ORCID http://orcid.org/0000-0001-6684-7982
University of Bonn · DEUniversity of Turku · FIEastern Finland Laboratory Center · FIÅbo Akademi University · FILoyola University Chicago · US

Funding

Academy of Finland 332589
6 · The paper itself

Abstract

ATP and adenosine have emerged as important signaling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulatory mechanisms of purinergic signaling in the eye. Here, we used three-dimensional multiplexed imaging, in situ enzyme histochemistry, flow cytometric analysis, and single cell transcriptomics to characterize the whole pattern of purine metabolism in mouse and human eyes. This study identified ecto-nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39), NTPDase2, and ecto-5'-nucleotidase/CD73 as major ocular ecto-nucleotidases, which are selectively expressed in the photoreceptor layer (CD73), optic nerve head, retinal vasculature and microglia (CD39), as well as in neuronal processes and cornea (CD39, NTPDase2). Specifically, microglial cells can create a spatially arranged network in the retinal parenchyma by extending and retracting their branched CD39

Indexed as

Light5'-NucleotidaseAdenosineAdenosine DiphosphateAdenosine TriphosphateAnimalsAntigens, CDApoptosisApyraseFemaleHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLMicroglia5'-NucleotidaseAdenosineAdenosine DiphosphateAdenosine Triphosphatealpha,beta-methyleneadenosine 5'-diphosphateAntigens, CDApyraseCD39 antigenAdenosine receptorsEcto-5′-nucleotidase/CD73Mouse and human retinaNTPDase1/CD39

Identifiers

PMID35212809
PMCPMC8881442
OpenAlexW4221034668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.