Evidence map›Paper›PMID 35212874›Full record

ArticleJournal of general internal medicine2022

Alcohol Use and Blood Pressure Among Adults with Hypertension: the Mediating Roles of Health Behaviors.

Aryn Z Phillips, Catarina I Kiefe, Cora E Lewis, Pamela J Schreiner, Gabriel S Tajeu, Mercedes R Carnethon

Abstract read
In one paragraph

Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Association of psychiatric history with hypertension among adults who present for metabolic and bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Article
  9. Article
  10. Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aryn Z PhillipsDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, 60611, USA. Aryn.phillips@northwestern.edu.ORCID 0000-0002-3221-1617
Catarina I KiefeDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Cora E LewisDepartment of Epidemiology, University of Alabama at Birmingham School of Public Health, 1665 University Boulevard, Birmingham, AB, 35233, USA.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
Gabriel S TajeuDepartment of Health Services Administration and Policy, Temple University College of Public Health, 1101 W. Montgomery Avenue, Philadelphia, PA, 19122, USA.
Mercedes R CarnethonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, 60611, USA.

Funding

RESEARCH TRAINING IN CVD EPIDEMIOLOGY AND PREVENTIONT32HL069771 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Mercedes Renee Carnethon · 2003 to 2026
$5.9M
Psychopathology, Disordered Eating, and Impulsivity as Predictors of Outcomes of Bariatric SurgeryR01DK108628 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI SARWER, DAVID B · 2015 to 2019
$2.1M
Machine Learning to Reduce Hypertension Treatment Clinical InertiaK01HL151974 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TAJEU, GABRIEL S · 2020 to 2024
$739k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K01 HL151974NHLBI NIH HHS T32 HL069771NIDDK NIH HHS R01 DK108628
6 · The paper itself

Abstract

backgroundAlcohol use is associated with increased blood pressure among adults with hypertension, but it is unknown whether some of the observed relationship is explained by mediating behaviors related to alcohol use.

objectiveWe assess the potential indirect role of smoking, physical inactivity, unhealthy diet, and poor medication adherence on the association between alcohol use and blood pressure among Black and White men and women with hypertension.

designAdjusted repeated-measures analyses using generalized estimating equations and mediation analyses using inverse odds ratio weighting.

participants1835 participants with hypertension based on ACC/AHA 2017 guidelines in three most recent follow-up exams of the longitudinal Coronary Artery Risk Development in Young Adults cohort study (2005-2016). MAIN MEASURES: Alcohol use was assessed using both self-reported average ethanol intake (drinks/day) and engagement in heavy episodic drinking (HED) in the past 30 days. Systolic and diastolic blood pressure (SBP, DBP) were measured by trained technicians (mmHg). Smoking, physical inactivity, and diet were self-reported and categorized according to American Heart Association criteria, and medication adherence was assessed using self-reported typical adherence to antihypertensive medications. KEY

resultsAt baseline (2005-2006), 57.9% of participants were Black and 51.4% were women. Mean age (standard deviation) was 45.5 (3.6) years, mean SBP was 128.7 (15.5) mmHg, and mean DBP was 83.2 (10.1) mmHg. Each additional drink per day was significantly associated with higher SBP (β = 0.713 mmHg, 95% confidence interval (CI): 0.398, 1.028) and DBP (β = 0.398 mmHg, 95% CI: 0.160, 0.555), but there was no evidence of mediation by any of the behaviors. HED was not associated with blood pressure independent of average consumption.

conclusionsThese findings support the direct nature of the association of alcohol use with blood pressure and the utility of advising patients with hypertension to limit consumption in addition to other behavioral and pharmacological interventions.

Indexed as

Antihypertensive AgentsHypertensionBlood PressureCohort StudiesEthanolFemaleHumansMaleMedication AdherenceMiddle AgedYoung AdultAntihypertensive AgentsEthanolalcohol useblood pressurehealth behaviorsmediation

Identifiers

PMID35212874
PMCPMC9551008

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.