Evidence map›Paper›PMID 35213686›Full record

ArticleBlood2022

Anemia in the pediatric patient.

Patrick G Gallagher

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Impact ofFrontiers in microbiology · 2025
    Pooled it
  5. Article
  6. Do Ethnicity/Caste-Based Disparities Influence Childhood Anemia in India?Journal of racial and ethnic health disparities · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Molecular and therapeutic frontiers in anemia therapy.The Journal of clinical investigation · 2026
    Review
  11. Inflammation, anemia, and vitamin D levels associate with infant thrombocytosis risk.Research and practice in thrombosis and haemostasis · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patrick G GallagherDepartments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7M
Regulation of Erythrocyte Volume HomeostasisR01DK104046 · NIDDK · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 2014 to 2020
$2.1M
Novel Mechanisms of Congenital Dyserythropoietic AnemiaR01DK111539 · NIDDK · YALE UNIVERSITY · PI GALLAGHER, PATRICK G, HENDRICKSON, JEANNE E · 2020 to 2023
$1.7M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P01 DK032094NIDDK NIH HHS R01 DK104046NIDDK NIH HHS R01 DK111539
6 · The paper itself

Abstract

The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases.

Indexed as

AnemiaAnemia, Iron-DeficiencyNervous System DiseasesChildChild, PreschoolGenetic TestingHumans

Identifiers

PMID35213686
PMCPMC9373018
OpenAlexW4214518267

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.