Evidence map›Paper›PMID 35214600›Full record

ArticleVaccines2022

Reduced Titers of Circulating Anti-SARS-CoV-2 Antibodies and Risk of COVID-19 Infection in Healthcare Workers during the Nine Months after Immunization with the BNT162b2 mRNA Vaccine.

Luca Coppeta, Cristiana Ferrari, Giuseppina Somma, Andrea Mazza, Umberto D'Ancona, Fabbio Marcuccilli, Sandro Grelli, Marco Trabucco Aurilio, Antonio Pietroiusti, Andrea Magrini and 1 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Luca CoppetaDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-2470-6107
Cristiana FerrariDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-2292-3338
Giuseppina SommaDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Andrea MazzaDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Umberto D'AnconaDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Fabbio MarcuccilliDepartment of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Sandro GrelliDepartment of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Marco Trabucco AurilioDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.ORCID 0000-0003-2327-1455
Antonio PietroiustiDepartmental Faculty of Medicine, University Unicamillus, 00131 Rome, Italy.
Andrea MagriniDepartment of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Stefano RizzaDepartment of System Medicine, University of Rome Tor Vergata, Viale Oxford 81, 00133 Roma, Italy.ORCID 0000-0001-5496-4890
University of Rome Tor Vergata · ITSaint Camillus International University of Health and Medical Sciences · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact on health services; hundreds of thousands of healthcare workers (HCWs) have died from coronavirus disease 2019 (COVID-19). The introduction of the BNT162b2 mRNA vaccine in Italy provided recipients with significant protection against COVID-19 within one to two weeks after the administration of the second of the two recommended doses. While the vaccine induces a robust T cell response, the protective role of factors and pathways other than those related to memory B cell responses to specific SARS-CoV-2 antigens remains unclear. This retrospective study aimed to evaluate the determinants of serological protection in a group of vaccinated HCWs (

Indexed as

anti-S-RBD antibodiesBNT162b2 mRNA vaccineCOVID-19healthcare workersSARS-CoV-2vaccine

Identifiers

PMID35214600
PMCPMC8879462
OpenAlexW4205986824

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.