Evidence map›Paper›PMID 35214645›Full record

ArticleVaccines2022

Ex Vivo Evaluation of Mucosal Responses to Vaccination with ALVAC and AIDSVAX of Non-Human Primates.

Carolina Herrera, Ronald Veazey, Melissa M Lemke, Kelly Arnold, Jerome H Kim, Robin J Shattock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Carolina HerreraDepartment of Medicine, Imperial College London, London W2 1PG, UK.ORCID 0000-0003-3701-752X
Ronald VeazeyTulane National Primate Research Center, School of Medicine, Tulane University, Covington, GA 70433, USA.ORCID 0000-0002-6298-2391
Melissa M LemkeDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Kelly ArnoldDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Jerome H KimUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MA 20817, USA.
Robin J ShattockDepartment of Medicine, Imperial College London, London W2 1PG, UK.ORCID 0000-0002-4936-1718
Imperial College London · GBUniversity of Michigan · USTulane University · USWalter Reed Army Institute of Research · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
CHAVI/HVTN Early Stage Investigator AwardNIH HHS P51 OD011104
6 · The paper itself

Abstract

Non-human primates (NHPs) remain the most relevant challenge model for the evaluation of HIV vaccine candidates; however, discrepancies with clinical trial results have emphasized the need to further refine the NHP model. Furthermore, classical evaluation of vaccine candidates is based on endpoints measured systemically. We assessed the mucosal responses elicited upon vaccination with ALVAC and AIDSVAX using ex vivo Rhesus macaque mucosal tissue explant models. Following booster immunization with ALVAC/AIDSVAX, anti-gp120 HIV-1

Indexed as

HIV-1mucosal immunologyvaccine

Identifiers

PMID35214645
PMCPMC8879115
OpenAlexW4210805085

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.