Evidence map›Paper›PMID 35215560›Full record

ArticleNutrients2022

Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model.

Laszlo Szabo, Richard Molnar, Andras Tomesz, Arpad Deutsch, Richard Darago, Timea Varjas, Zsombor Ritter, Jozsef L Szentpeteri, Kitti Andreidesz, Domokos Mathe and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Curcumin in High Doses Reverses the UV-B-InducedPharmaceuticals (Basel, Switzerland) · 2026
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  3. Review
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  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Laszlo SzaboDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Richard MolnarDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Andras TomeszDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Arpad DeutschDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Richard DaragoDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Timea VarjasDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Zsombor RitterDepartment of Medical Imaging, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-2898-1571
Jozsef L SzentpeteriInstitute of Transdisciplinary Discoveries, Medical School, University of Pécs, 7624 Pécs, Hungary.
Kitti AndreideszDepartment of Biochemistry and Medical Chemistry, University of Pécs Medical School, 7624 Pécs, Hungary.
Domokos MatheDepartment of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-7343-0413
Imre HegedüsDepartment of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-1438-3511
Attila SikInstitute of Transdisciplinary Discoveries, Medical School, University of Pécs, 7624 Pécs, Hungary.
Ferenc BudanDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0003-1562-9496
Istvan KissDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
University of Pecs · HUSemmelweis University · HU

Funding

European Union 712821
6 · The paper itself

Abstract

DNA methylation is an epigenetic mechanism that is crucial for mammalian development and genomic stability. Aberrant DNA methylation changes have been detected not only in malignant tumor tissues; the decrease of global DNA methylation levels is also characteristic for aging. The consumption of extra virgin olive oil (EVOO) as part of a balanced diet shows preventive effects against age-related diseases and cancer. On the other hand, consuming trans fatty acids (TFA) increases the risk of cardiovascular diseases as well as cancer. The aim of the study was to investigate the LINE-1 retrotransposon (L1-RTP) DNA methylation pattern in liver, kidney, and spleen of mice as a marker of genetic instability. For that, mice were fed with EVOO or TFA and were pretreated with environmental carcinogen 7,12-dimethylbenz[a]anthracene (DMBA)-a harmful substance known to cause L1-RTP DNA hypomethylation. Our results show that DMBA and its combination with TFA caused significant L1-RTP DNA hypomethylation compared to the control group via inhibition of DNA methyltransferase (DNMT) enzymes. EVOO had the opposite effect by significantly decreasing DMBA and DMBA + TFA-induced hypomethylation, thereby counteracting their effects.

Indexed as

Carcinogens, EnvironmentalTrans Fatty AcidsAnimalsDNA MethylationMiceOlive OilRetroelementsCarcinogens, EnvironmentalOlive OilRetroelementsTrans Fatty AcidsDMBAextra virgin olive oilLINE-1 methylation patterntrans fatty acid

Identifiers

PMID35215560
PMCPMC8878525
OpenAlexW4213189621

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.