Evidence map›Paper›PMID 35216416›Full record

ArticleInternational journal of molecular sciences2022

Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears.

Michiel Van Bulck, Nicola Brandt, Ralf A Claus, Markus Gräler, Anja U Bräuer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Michiel Van BulckResearch Group Anatomy, School for Medicine and Health Science, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.ORCID 0000-0003-0253-4914
Nicola BrandtResearch Group Anatomy, School for Medicine and Health Science, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
Ralf A ClausDepartment of Anaesthesiology and Intensive Care Medicine Center for Molecular Biomedicine(CMB), Jena University Hospital, 07745 Jena, Germany.ORCID 0000-0001-7232-4088
Markus GrälerDepartment of Anaesthesiology and Intensive Care Medicine Center for Molecular Biomedicine(CMB), Jena University Hospital, 07745 Jena, Germany.ORCID 0000-0001-6650-7849
Anja U BräuerResearch Group Anatomy, School for Medicine and Health Science, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.ORCID 0000-0003-3651-1470
Carl von Ossietzky Universität Oldenburg · DEJena University Hospital · DE

Funding

Marie Skłodowska-Curie Innovative Training Network H2020 MSCA-ITN-ETN No. 721281
6 · The paper itself

Abstract

Loss of active synapses and alterations in membrane lipids are crucial events in physiological aging as well as in neurodegenerative disorders. Both are related to the abnormal aggregation of amyloid-beta (Aβ) species, generally known as amyloidosis. There are two major known human Aβ species: Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCells, CulturedHippocampusMembrane LipidsMiceMice, Inbred C57BLNeuronsSynapsesAmyloid beta-PeptidesMembrane LipidsAlzheimers diseaseAβ speciescell-communicationglia cellsmembrane lipidsneuronessynapses

Identifiers

PMID35216416
PMCPMC8877175
OpenAlexW4213268863

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.