Evidence map›Paper›PMID 35217250›Full record

ArticleEuropean journal of radiology2022

Organ doses and cancer risk assessment in patients exposed to high doses from recurrent CT exams.

Nahom Zewde, Francesco Ria, Madan M Rehani

Abstract read
In one paragraph

Article in European journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Can clinicians identify community-acquired pneumonia on ultralow-dose CT? A diagnostic accuracy study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Patients undergoing multipleThe British journal of radiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nahom ZewdeEarlham College, Richmond, IN 47374, USA. Electronic address: ntzewde18@earlham.edu.
Francesco RiaCarl E. Ravin Advanced Imaging Labs and Clinical Imaging Physics Group, Duke University Health System, Durham, NC 27710, USA.
Madan M RehaniMassachusetts General Hospital, Boston, USA.

Funding

Quality and Safety Monitoring of Clinical Computed Tomography PracticeR44EB031658 · NIBIB · METIS HEALTH ANALYTICS, LLC · PI SAPP, ARMISTEAD WRIGHT · 2021 to 2023
$1.9M
NIBIB NIH HHS R44 EB031658
6 · The paper itself

Abstract

purposeTo estimate cumulative organ doses and age- and gender-stratified cancer mortality risks in patients undergoing recurrent computed tomography (CT) exams.

methodsCohorts of patients who received cumulative effective dose ≥ 100 mSv were stratified into age and gender groups. Organ doses of 27 organs using Monte Carlo methods were available, and the relative risk model from the Biological Effects of Ionizing Radiation VII (BEIR VII) was used to estimate lifetime attributable cancer mortality risks (LACMR).

resultsOut of the 8956 patients, 6.7% were 16-44 years of age, with median organ doses higher than 200 mGy for stomach and liver, whereas organ doses for nine organs, which included lungs, breasts, colon, red bone marrow, urinary bladder, esophagus, testicles, ovaries, and skin were between 100 and 200 mGy. Thyroid and salivary glands had smaller doses in the range of 45-69 mGy, but the mean dose for each organ was over 100 mGy. The age- and gender-specific median LACMR for the 16-44-years cohort was 0.6 to 0.7 deaths per 100 individuals for males, and 0.8 for females. The mortality estimated figures were highest for patients 16-54 years with slightly lower values for older age groups. Except for the highest age bracket of 75-84 years, the LACMR values for 55-74 years are not lower by orders of magnitude, and thus one cannot ignore risks in this age group.

conclusionsOrgan doses over 100 mGy for most organs and for some organs ≥ 200 mGy with unignorable associated lifetime attributable cancer mortality rates were found.

Indexed as

NeoplasmsAgedAged, 80 and overFemaleHumansMaleMonte Carlo MethodPhantoms, ImagingRadiation DosageRisk AssessmentTomography, X-Ray ComputedCancer risk CTComputed tomography dosesCumulative dosesOrgan doses CTRadiation risk CT

Identifiers

PMID35217250
PMCPMC11931570

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.