Evidence map›Paper›PMID 35217585›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk.

Javeed A Shah, Alex J Warr, Andrew D Graustein, Aparajita Saha, Sarah J Dunstan, Nguyen T T Thuong, Guy E Thwaites, Maxine Caws, Phan V K Thai, Nguyen D Bang and 16 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Risk Genetic Variants (Journal of inflammation research · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 7 countries.

Javeed A ShahUniversity of Washington, Seattle, WA; jashah@uw.edu.ORCID 0000-0002-2997-7988
Alex J WarrUniversity of Washington, Seattle, WA.
Andrew D GrausteinUniversity of Washington, Seattle, WA.
Aparajita SahaUniversity of Washington, Seattle, WA.ORCID 0000-0002-5014-6687
Sarah J DunstanUniversity of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-7873-933X
Nguyen T T ThuongOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Guy E ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Maxine CawsLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Phan V K ThaiPham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.
Nguyen D BangPham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.
Tran T H ChauPham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam.
Chiea Chuen KhorGenome Institute of Singapore, A-STAR, Singapore.
Zheng LiGenome Institute of Singapore, A-STAR, Singapore.
Martin HibberdLondon School of Tropical Medicine and Hygiene, London, United Kingdom.
Xuling ChangUniversity of Melbourne, Melbourne, Victoria, Australia.
Felicia K NguyenUniversity of Washington, Seattle, WA.ORCID 0000-0002-3279-2933
Carlo A HernandezUniversity of Washington, Seattle, WA.
Madison A JonesUniversity of Washington, Seattle, WA.
Christopher M SassettiUniversity of Massachusetts, Worchester, MA; and.
Katherine A FitzgeraldUniversity of Massachusetts, Worchester, MA; and.
Munyaradzi MusvosviSouth African Tuberculosis Vaccine Initiative, Cape Town, South Africa.
Anele GelaSouth African Tuberculosis Vaccine Initiative, Cape Town, South Africa.
Willem A HanekomSouth African Tuberculosis Vaccine Initiative, Cape Town, South Africa.
Mark HatherillSouth African Tuberculosis Vaccine Initiative, Cape Town, South Africa.ORCID 0000-0003-3491-1809
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Cape Town, South Africa.ORCID 0000-0002-0641-1359
Thomas R HawnUniversity of Washington, Seattle, WA.
University of Washington · USSouth African Tuberculosis Vaccine Initiative · ZAPham Ngoc Thach Hospital · VNAgency for Science, Technology and Research · SGAngkor Hospital for Children · KHThe University of Melbourne · AUUniversity of Massachusetts Chan Medical School · USLiverpool School of Tropical Medicine · GBUniversity of London · GB

Funding

Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Gene Regulation in Innate ImmunityR37AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2015 to 2024
$4.6M
TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis SusceptibilityR01AI136921 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2018 to 2022
$2.5M
Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseR01AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2006 to 2010
$2.0M
Pulmonary Innate Immunity & Resistance to Mycobacterium Tuberculosis InfectionK24AI137310 · NIAID · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R · 2018 to 2022
$892k
TOLLIP and Tuberculosis ImmunopathogenesisK08AI102971 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2013 to 2016
$708k
The impact of mucociliary clearance on Mycobacterium tuberculosis pathogenesisR21AI165961 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2023 to 2024
$457k
Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseR56AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2012 to 2012
$415k
Acquisition of BD FACSymphony A3 Lite Flow CytometerS10OD024979 · OD · UNIVERSITY OF WASHINGTON · PI BLACK, MICHELE C · 2020 to 2020
$344k
NIAID NIH HHS K08 AI102971NIAID NIH HHS K24 AI137310NIAID NIH HHS P01 AI132130NIAID NIH HHS R01 AI067497NIAID NIH HHS R01 AI136921NIAID NIH HHS R21 AI165961NIAID NIH HHS R37 AI067497NIAID NIH HHS R56 AI067497NIH HHS S10 OD024979Wellcome Trust 206724/Z/17/Z
6 · The paper itself

Abstract

The major human genes regulating

Indexed as

Mycobacterium bovisMycobacterium tuberculosisTuberculosisAdultBasic Helix-Loop-Helix ProteinsBCG VaccineChildHomeodomain ProteinsHumansInterleukin-10Interleukin-12Proto-Oncogene Proteins c-relBasic Helix-Loop-Helix ProteinsBCG VaccineBHLHE40 protein, humanHomeodomain ProteinsInterleukin-10Interleukin-12Proto-Oncogene Proteins c-relREL protein, human

Identifiers

PMID35217585
PMCPMC8917052
OpenAlexW4214499529

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.