Evidence map›Paper›PMID 35217620›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

ERK signaling dissolves ERF repression condensates in living embryos.

Claire J Weaver, Aleena L Patel, Stanislav Y Shvartsman, Michael S Levine, Nicholas Treen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Model of neural induction in the ascidian embryo.PLoS computational biology · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claire J WeaverLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Aleena L PatelLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Stanislav Y ShvartsmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Michael S LevineLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544; msl2@princeton.edu ntreen@princeton.edu.
Nicholas TreenLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544; msl2@princeton.edu ntreen@princeton.edu.
Princeton University · US

Funding

Developmental Patterning of the Anterior Neural Plate in a Simple ChordateR01NS076542 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVINE, MICHAEL STEVEN · 2012 to 2022
$3.4M
NINDS NIH HHS R01 NS076542
6 · The paper itself

Abstract

Phase separation underlies the organization of the nucleus, including the biogenesis of nucleoli and the packaging of heterochromatin. Here we explore the regulation of transcription factor condensates involved in gene repression by ERK signaling in gastrulating embryos of a simple proto-vertebrate (

Indexed as

Signal TransductionAnimalsCionaExtracellular Signal-Regulated MAP KinasesHumansRepressor ProteinsERF protein, humanExtracellular Signal-Regulated MAP KinasesRepressor Proteinsdevelopmental biologyphase separationtranscriptional repression

Identifiers

PMID35217620
PMCPMC8892517
OpenAlexW4220837509

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.