Evidence map›Paper›PMID 35218041›Full record

ArticleAnnals of the New York Academy of Sciences2022

Bioactive lipids and metabolic syndrome-a symposium report.

Loren M DeVito, Edward A Dennis, Barbara B Kahn, Gerald I Shulman, Joseph L Witztum, Sudeshna Sadhu, Joseph Nickels, Matthew Spite, Susan Smyth, Sarah Spiegel

Open access · greenAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Adipose tissue-derived lipokines in metabolism.Current opinion in genetics & development · 2023
    Review
  4. Review
  5. Article
  6. CRP/HDL-C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Loren M DeVitoSticky Ink, Inc., New York, New York.
Edward A DennisUniversity of California San Diego, La Jolla, California.
Barbara B KahnBeth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Gerald I ShulmanYale School of Medicine, New Haven, Connecticut.
Joseph L WitztumUniversity of California San Diego, La Jolla, California.
Sudeshna SadhuAlbany Medical College, Albany, New York.
Joseph NickelsGenesis Biotechnology Group, Hamilton Township, New Jersey.
Matthew SpiteBeth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Susan SmythUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas.
Sarah SpiegelVirginia Commonwealth University School of Medicine, Richmond, Virginia.
University of California San Diego · USAlbany Medical Center Hospital · USBeth Israel Deaconess Medical Center · USFaculty of 1000 (United States) · USGenesis HealthCare · USHarvard University · USUniversity of Arkansas for Medical Sciences · USVirginia Commonwealth University · USYale University · US

Funding

Regulation of the biosynthesis of a novel class of anti-diabetic lipidsR01DK106210 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B., SAGHATELIAN, ALAN · 2016 to 2024
$6.6M
GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETESR01DK043051 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B. · 1992 to 2020
$4.4M
SPHINGOSINE AS A MODULATOR OF CELLULAR PROLIFERATIONR01GM043880 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 1990 to 2023
$3.8M
Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
NIDDK NIH HHS R01 DK043051NIDDK NIH HHS R01 DK106210NIGMS NIH HHS R01 GM043880NIGMS NIH HHS R35 GM139641
6 · The paper itself

Abstract

Recent research has shed light on the cellular and molecular functions of bioactive lipids that go far beyond what was known about their role as dietary lipids. Bioactive lipids regulate inflammation and its resolution as signaling molecules. Genetic studies have identified key factors that can increase the risk of cardiovascular diseases and metabolic syndrome through their effects on lipogenesis. Lipid scientists have explored how these signaling pathways affect lipid metabolism in the liver, adipose tissue, and macrophages by utilizing a variety of techniques in both humans and animal models, including novel lipidomics approaches and molecular dynamics models. Dissecting out these lipid pathways can help identify mechanisms that can be targeted to prevent or treat cardiometabolic conditions. Continued investigation of the multitude of functions mediated by bioactive lipids may reveal additional components of these pathways that can provide a greater understanding of metabolic homeostasis.

Indexed as

Metabolic SyndromeAnimalsDietary FatsHomeostasisHumansLipid MetabolismLipidsDietary FatsLipidsbioactive lipidscardiometabolic diseaseinflammationlipid mediatorslipid metabolism

Identifiers

PMID35218041
PMCPMC9219555
OpenAlexW4214687531

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.