Evidence map›Paper›PMID 35220425›Full record

SynthesisHuman molecular genetics2022

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes.

Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P Cook, Catherine Allard, Robin N Beaumont, Mickaël Canouil, Gad Hatem, Anni Heiskala and 63 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 11 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 11 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors at 20 institutions in 14 countries.

Natalia PervjakovaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Gunn-Helen MoenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-8768-0904
Maria-Carolina BorgesPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Teresa FerreiraBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
James P CookDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
Catherine AllardCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universite de Sherbrooke, Quebec, Canada.ORCID 0000-0002-8829-4984
Robin N BeaumontInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK.ORCID 0000-0003-0750-8248
Mickaël CanouilInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Gad HatemDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.
Anni HeiskalaCentre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Anni JoensuuDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
Ville KarhunenCentre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Soo Heon KwakDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Frederick T J LinDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jun LiuDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Sheryl Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Claudia H TamDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China.
Wing Hung TamDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Toby AndrewInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Juha AuvinenCentre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Bishwajit BhowmikCentre of Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh.
Amélie BonnefondInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Fabien DelahayeInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Ayse DemirkanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Philippe FroguelInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Kadri Haller-KikkataloDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Hildur HardardottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Sandra HummelInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Akhtar HussainCentre of Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh.
Eero KajantiePopulation Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.
Elina KeikkalaPopulation Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.
Amna KhamisInserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Tove LekvaResearch Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Sanna MustaniemiPopulation Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.
Christine SommerDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Aili TagomaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Evangelia TzalaSchool of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Hospital, London, UK.
Raivo UiboDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Marja VääräsmäkiPEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Pia M VillaDepartment of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kåre I BirkelandInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Luigi BouchardDepartment of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Quebec, Canada.
Cornelia M DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Sarah FinerCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Leif GroopDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.
Esa HämäläinenDepartment of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland.
Geoffrey M HayesDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Graham A HitmanCentre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Hak C JangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Marjo-Riitta JärvelinCentre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Anne Karen JenumGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, Faculty of Medicine, University of Oslo, Post Box 1130 Blindern, Oslo 0318, Norway.
Hannele LaivuoriInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Ronald C MaDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China.
Olle MelanderDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Kyong Soo ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Patrice PerronCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universite de Sherbrooke, Quebec, Canada.
Rashmi B PrasadDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.
Elisabeth QvigstadDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Sylvain SebertCentre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Valgerdur SteinthorsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Tiinamaija TuomiInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Paul W FranksDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Cecilia M LindgrenBig Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
Rachel M FreathyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK.
Deborah A LawlorPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Andrew P MorrisCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-6805-6014
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.ORCID 0000-0002-2964-6011
Centre National de la Recherche Scientifique · FRUniversity of Helsinki · FIOslo University Hospital · NOUniversité de Sherbrooke · CAChinese University of Hong Kong · HKdeCODE Genetics (Iceland) · ISErasmus MC · NLHarvard University · USLund University · SEOulu University Hospital · FISt Mary's Hospital · GBUniversity of Oulu · FIUniversity of Tartu · EEAt Bristol · GBEstonian Academy of Sciences · EENorthwestern University · USQueen Mary University of London · GBSeoul National University · KRUniversity of Exeter · GBBroad Institute · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
British Heart Foundation CH/F/20/90003British Heart Foundation CS/16/4/32482Medical Research Council MC_UU_00011/6Medical Research Council MR/N024397/1Medical Research Council MR/R010676/1Medical Research Council MR/S03658X/1NICHD NIH HHS R01 HD034568NIH HHS UH3 OD023286Wellcome Trust
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy Consortium assembled genome-wide association studies of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (P < 5 × 10-8) with GDM, mapping to/near MTNR1B (P = 4.3 × 10-54), TCF7L2 (P = 4.0 × 10-16), CDKAL1 (P = 1.6 × 10-14), CDKN2A-CDKN2B (P = 4.1 × 10-9) and HKDC1 (P = 2.9 × 10-8). Multiple lines of evidence pointed to the shared pathophysiology of GDM and T2D: (i) four of the five GDM loci (not HKDC1) have been previously reported at genome-wide significance for T2D; (ii) significant enrichment for associations with GDM at previously reported T2D loci; (iii) strong genetic correlation between GDM and T2D and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. Mendelian randomization analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGlucoseHumansPolymorphism, Single NucleotidePregnancyGlucose

Identifiers

PMID35220425
PMCPMC9523562
OpenAlexW4214500137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.