Evidence map›Paper›PMID 35220552›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

RNA modification "writer"-mediated RNA modification patterns and tumor microenvironment characteristics of cervical cancer.

Yanjun Qu, Hong Zhu, Congcong Kong, Xin Zheng, Dejun Wang, Xiuwei Chen, Dandan Yuan

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yanjun Qu *Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, postal street, Nangang District, Harbin City, PCODE:230100, Heilongjiang Province, China.
Hong Zhu *Department of Gynecological Oncology, Renji Hospital Affiliated To Medical College of Shanghai Jiaotong University, 160 Pujian Road, Pudong New Area, Shanghai, 310000, China.
Congcong KongDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, postal street, Nangang District, Harbin City, PCODE:230100, Heilongjiang Province, China.
Xin ZhengDepartment of Gynecology, The First Hospital of Jiaxing, 1882 Zhonghuan South Road, Nanhu District, Jiaxing City, PCODE:330400, Zhejiang Province, China.
Dejun WangDepartment of Gynecology, The First Affiliated Hospital of Harbin Medical University, No. 23, postal street, Nangang District, Harbin City, PCODE:230100, Heilongjiang Province, China.
Xiuwei ChenDepartment of Gynecology, The Third Affiliated Hospital of Harbin Medical University, No. 150, haping Road, health care road street, Nangang District, Harbin City, PCODE:230100, Heilongjiang Province, China.
Dandan YuanDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin, PCODE:230100, Heilongjiang Province, China. yuandandan_80@163.com.ORCID http://orcid.org/0000-0003-1027-7751
Harbin Medical University · CNFirst Hospital of Jiaxing · CNRenji Hospital · CN

Funding

Heilongjiang Provincial Natural Science Foundation of China LH2019H021
6 · The paper itself

Abstract

purposeAs an epigenetic regulation mechanism after transcription, RNA modification is installed by endogenous "writer" enzymes and is widely involved in a variety of physiological processes, including cancer progression. This study explored the RNA modification patterns of cervical cancer to clarify overall effect of RNA modification on tumor microenvironment (TME) characteristics and immune/targeted therapy.

methods26 RNA modification "writers" were clustered, and the RNA modification patterns and TME characteristics of cervical cancer patients in TCGA were systematically evaluated. Based on differentially expressed genes (DEGs) between different RNA modification patterns, an RNA modification "writer" score (WM score) system was developed to assess the RNA modification of a single sample.

resultsTwo different RNA modification patterns of cervical cancer were identified, and these patterns were significantly related to the prognosis and TME infiltration characteristics of patients. WM score was an independent risk factor for the prognosis of cervical cancer. High WM score was characterized by poor prognosis, low immune infiltration and low tumor mutation burden (TMB), while low-WM score was related to relatively long overall survival (OS), more immune components in TME and increased TMB. In addition, the low-WM score group was expected to be more sensitive to programmed cell death protein 1 (PD-1) therapy and showed lower predicted IC

conclusionsThis study identified and characterized RNA modification patterns, and clarified potential relationship between RNA modification patterns and immune infiltration characteristics and immunotherapy of cervical cancer, offering a new evaluation scheme for treatment of cervical cancer patients.

Indexed as

Tumor MicroenvironmentUterine Cervical NeoplasmsBiomarkers, TumorEpigenesis, GeneticFemaleHumansPrognosisRNABiomarkers, TumorRNACervical cancerImmunotherapyRNA modification “writers”Tumor microenvironmentWM score

Identifiers

PMID35220552
OpenAlexW4214707661

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.