ArticleJournal of diabetes investigation2022
Metabolic Score for Insulin Resistance, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin-to-creatinine ratio in Chinese adults: A cross-sectional REACTION study.
Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Prognostic value of four insulin resistance indices in predicting new-onset hypertension: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association of surrogate indices of insulin resistance with hypertension: a cross-sectional analysis from PERSIAN Dena cohort study (PDCS).Scientific reports · 2025Article
- Dietary flavonoids may improve insulin resistance: NHANES, network pharmacological analyses and in vitro experiments.PloS one · 2025Article
- Relationship between METS-IR and ABSI index and the prevalence of nocturia: a cross-sectional analysis from the 2005-2020 NHANES data.Scientific reports · 2024Article
- Non-Insulin-Based Indices of Insulin Resistance for Predicting Incident Albuminuria: A Nationwide Population-Based Study.Korean journal of family medicine · 2024Article
- The U-shape relationship between insulin resistance-related indexes and chronic kidney disease: a retrospective cohort study from National Health and Nutrition Examination Survey 2007-2016.Diabetology & metabolic syndrome · 2024Article
- Kidney and liver fat accumulation: from imaging to clinical consequences.Journal of nephrology · 2024Article
- Metabolic Score for Insulin Resistance, a novel score to evaluate insulin sensitivity, is associated with the urinary albumin-to-creatinine ratio in Chinese adults: A cross-sectional REACTION study.Journal of diabetes investigation · 2022Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
AIMS/
introductionThe Metabolic Score for Insulin Resistance (METS-IR) is a novel non-insulin-based metabolic index used as a substitution marker of insulin resistance. However, whether METS-IR is associated with the urinary albumin-to-creatinine ratio (UACR) is not well known. Therefore, we explored the associations between METS-IR and UACR, and compared the discriminative ability of METS-IR and its components for elevated UACR. MATERIALS AND
methodsThis study included 37,290 participants. METS-IR was calculated as follows: (Ln[2 × fasting blood glucose + fasting triglyceride level] × body mass index) / (Ln [high-density lipoprotein cholesterol]). Participants were divided into four groups on the basis of METS-IR: <25%, 25-49%, 50-74% and ≥75%. Logistic regression analyses were carried out to determine the associations between METS-IR versus its components (fasting blood glucose, triglyceride level, body mass index and high-density lipoprotein cholesterol) with UACR.
resultsParticipants with the highest quartile METS-IR presented a more significant trend toward elevated UACR than toward its components (odds ratio 1.260, 95% confidence interval 1.152-1.378, P < 0.001 in all participants; odds ratio 1.321, 95% confidence interval 1.104-1.579, P = 0.002 in men; odds ratio 1.201, 95% confidence interval 1.083-1.330, P < 0.001 in women). There were significant associations between METS-IR and UACR in younger participants (aged <65 years for women and aged 55-64 years for men). Increased METS-IR was significantly associated with UACR in men with fasting blood glucose ≥5.6 or postprandial blood glucose ≥7.8 mmol/L and systolic blood pressure ≥120 or diastolic blood pressure ≥80 mmHg. The relationships were significant in women with diabetes and hypertension.
conclusionsIncreased METS-IR was significantly associated with elevated UACR, its discriminative power for elevated UACR was superior to that of its components.
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