Evidence map›Paper›PMID 35221838›Full record

ArticleEXCLI journal2022

Hypermethylation of

Danuta Galetzka, Julia Böck, Lukas Wagner, Marcus Dittrich, Olesja Sinizyn, Marco Ludwig, Heidi Rossmann, Claudia Spix, Markus Radsak, Peter Scholz-Kreisel and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EXCLI journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Danuta GaletzkaDepartment of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany.
Julia BöckInstitute of Human Genetics, Julius Maximilians University, Würzburg, Germany.
Lukas WagnerCenter for Pediatrics and Adolescent Medicine, University Medical Centre, Mainz, Germany.
Marcus DittrichBioinformatics Department, Julius Maximilians University, Würzburg, Germany.
Olesja SinizynDepartment of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany.
Marco LudwigDRK Medical Centre, Alzey, Germany.
Heidi RossmannInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Centre, Mainz, Germany.
Claudia SpixDivision of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Mainz, Germany.
Markus RadsakDepartment of Hematology, University Medical Centre, Mainz, Germany.
Peter Scholz-KreiselFederal Office of Radiation, Neuherberg, Germany.
Johanna MirschRadiation Biology and DNA Repair, Technical University of Darmstadt, Germany.
Matthias LinkeInstitute of Human Genetics, University Medical Centre, Mainz, Germany.
Walburgis BrennerDepartment of Obstetrics and Women's Health, University Medical Centre, Mainz, Germany.
Manuela MarronLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Alicia PoplawskiInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Mainz, Germany.
Thomas HaafInstitute of Human Genetics, Julius Maximilians University, Würzburg, Germany.
Heinz SchmidbergerDepartment of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany.
Dirk PrawittCenter for Pediatrics and Adolescent Medicine, University Medical Centre, Mainz, Germany.
Johannes Gutenberg University Mainz · DEUniversity of Würzburg · DELeibniz Institute for Prevention Research and Epidemiology - BIPS · DEMedical Genetics Center · DETechnical University of Darmstadt · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. However, risk factors might trigger the oncogenic transformation of cells. Among other regulatory signals, hypermethylation of

Indexed as

childhood cancerDNA repairhypermethylationleukemiaRAD9Aregular body cellssomatic mosaicism

Identifiers

PMID35221838
PMCPMC8859646
OpenAlexW4225904116

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.