ArticleFrontiers in neurology2022
Penumbra Detection With Oxygen Extraction Fraction Using Magnetic Susceptibility in Patients With Acute Ischemic Stroke.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Analysis of acute stroke-like lesions in MELAS: Distribution, potential boundaries and spreading pattern.Neuroimage. Reports · 2026Article
- The Role of Brain Frailty in Stroke Outcomes: A Systematic Review.Neurology international · 2026Review
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Science advances · 2026Article
- Article
- Relationship of ASPECTS Lesion Topography with Clinical Outcomes in Acute Ischemic Stroke Treated with Endovascular Thrombectomy: A Single-Center Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- The use of brain-specific biomarkers in urine for prediction of neurological outcome and extent of tissue damage following stroke.Scientific reports · 2025Article
- Plasma Cystine as a Marker of Acute Stroke Severity.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluating Deep Learning-Based Commercial Software for Detecting Ischemic Lesions on DWI in Stroke Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Integration of EHR and ECG Data for Predicting Paroxysmal Atrial Fibrillation in Stroke Patients.Bioengineering (Basel, Switzerland) · 2025Article
- Comparison of Brain Oxygen Metabolic Parameters Between Constrained qBOLD and Whole-Brain Oximetric Methods at Baseline and in Response to a Physiologic Stimulus.NMR in biomedicine · 2025Article
- Identification of Differential Proteins in Thrombi of Cardioembolic and Atherothrombotic Etiology in Patients with Ischemic Stroke.International journal of molecular sciences · 2025Article
- Stroke burden in North Africa and the Middle East, 1990-2021: an analysis based on the global burden of disease study.BMC neurology · 2025Article
- The expression changes endothelial and fibrinolytic biomarkers in acute ischemic stroke patients with OSA.BMC neurology · 2025Article
- Prediction of prognosis in acute ischemic stroke after mechanical thrombectomy based on multimodal MRI radiomics and deep learning.Frontiers in neurology · 2025Article
- Association between iron content in grey matter nuclei and functional outcome in patients with acute ischaemic stroke: A quantitative susceptibility mapping study.European journal of neurology · 2025Article
- Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study.Frontiers in neurology · 2025Article
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Clinical value of thromboelastography in predicting the risk of recurrence of acute ischemic stroke.Frontiers in neurology · 2024Article
- Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.Frontiers in neurology · 2024Article
- Prognostic value of multi-PLD ASL-based cerebral perfusion ASPECTS in acute ischemic stroke.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oxygen extraction fraction (OEF) has been applied to identify ischemic penumbral tissue, but is difficult to use in an urgent care setting. This study aimed to investigate whether an OEF map generated via magnetic resonance quantitative susceptibility mapping (QSM) could help identify the ischemic penumbra in patients with acute ischemic stroke. MATERIALS AND
methodsThis prospective imaging study included 21 patients with large anterior circulation vessel occlusion who were admitted <24 h after stroke onset and 21 age-matched healthy controls. We identified the ischemic penumbra as the region with a Tmax of >6 s during dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) and calculated the perfusion-core mismatch ratio between the ischemic penumbra and infarct core volumes. The OEF values were measured based on magnetic susceptibility differences between the venous structures and brain tissues using rapid QSM acquisition. Volumes with increased OEF values were compared to the ischemic penumbra volumes using an anatomical template.
resultsEleven patients had a perfusion-core mismatch ratio of ≥1.8, and reperfusion therapy was recommended. In these patients, the volumes with increased OEF values of >51.5%, which was defined using the anterior circulation territory OEF values from the 21 healthy controls, were positively correlated with the ischemic penumbra volumes (
conclusionTissue volumes with increased OEF values could predict ischemic penumbra volumes based on DSC-MRI, highlighting the potential of the QSM-derived OEF map as a penumbra biomarker to guide treatment selection in patients with acute ischemic stroke.
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