ArticleFrontiers in endocrinology2022
High Remnant Cholesterol Level Potentiates the Development of Hypertension.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts incident hypertension: a 9-year prospective cohort study in Chinese adults.BMC cardiovascular disorders · 2026Article
- Association between remnant cholesterol level and gout in US adults.The Journal of international medical research · 2026Article
- Cumulative exposure to remnant cholesterol and new-onset hypertension in middle-aged and older adults: a nationwide prospective cohort study with mediation analysis.Journal of human hypertension · 2026Article
- Association between remnant cholesterol and isolated diastolic hypertension in young adults: a cross-sectional study in China.BMC cardiovascular disorders · 2026Article
- Association between Remnant Cholesterol and Metabolic Syndrome beyond Conventional Lipid Parameters in Middle Age and Elderly Population: Bushehr Elderly Health (BEH) cohort.Journal of diabetes and metabolic disorders · 2025Article
- Article
- Exploring the relationship between residual cholesterol, body mass index, and hypertension risk: a national cohort study.Lipids in health and disease · 2025Observational
- Cholesterol's hidden impact: the nonlinear link between remnant cholesterol (RC) and phenotypic age acceleration (PhenoAgeAccel).Biogerontology · 2025Article
- Association of remnant cholesterol with depression, type 2 diabetes, and their coexistence.BMC psychiatry · 2025Article
- Article
- Beyond LDL cholesterol: remnant cholesterol is associated with cardiometabolic risk factors in children.BMC medicine · 2025Article
- Remnant cholesterol, not LDL cholesterol, is associated with the risk of hypertension in the middle-aged and elderly population: Bushehr Elderly Health cohort.Frontiers in cardiovascular medicine · 2025Article
- Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study.Frontiers in endocrinology · 2025Article
- Combined and mediating effects of remnant cholesterol and renal function on hypertension risk in Chinese middle-aged and elderly people.Frontiers in endocrinology · 2025Article
- Remnant cholesterol, lipid ratios, and the severity of coronary artery lesions: a retrospective cohort study in patients with coronary heart disease.Frontiers in cardiovascular medicine · 2025Article
- Joint Association of Remnant Cholesterol and Body Mass Index with Hypertension: A National Cohort Study in Chinese Adults.Journal of multidisciplinary healthcare · 2025Article
- Linking Lipid Profile to Stress Urinary Incontinence in US Women: A National Cross-Sectional Study.International journal of women's health · 2025Article
- Cardiometabolic implications of triglyceride-glucose index, remnant cholesterol, and vitamin D in normoglycemic Arab adolescents: a cross-sectional study.Frontiers in endocrinology · 2025Observational
- Impact of remnant cholesterol on short-term mortality in acute decompensated heart failure: cohort study evidence from Jiangxi, China.Frontiers in endocrinology · 2025Article
- Association of remnant cholesterol with insulin resistance and type 2 diabetes: mediation analyses from NHANES 1999-2020.Lipids in health and disease · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emerging evidence suggests an association between remnant cholesterol (RC) and vascular damage and hypertension. However, this association has not been explored in a large-scale population in China, and a temporal relationship between RC and hypertension also needs to be investigated. Methods: We conducted a retrospective cross-sectional study in 2,199,366 individuals and a longitudinal study in 24,252 individuals with repeated measurements of lipid profile and blood pressure in at least a 3-year follow-up. The logistic model was used to explore the association between lipid components and hypertension in the cross-sectional analysis. The Cox model was used to analyze the association between high RC (HRC) at baseline and the subsequent incidence of hypertension or the association between hypertension at baseline and incidence of HRC. The cross-lagged panel model was applied to analyze the temporal relationship between RC and hypertension. Results: RC level as a continuous variable had the highest correlation with hypertension among lipid profiles, including RC, low-density lipoprotein cholesterol, total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides, with an odds ratio of 1.59 (95% confidence interval: 1.58-1.59). In the longitudinal cohort, HRC at baseline was associated with incident hypertension. We further explored the temporal relationship between RC and hypertension using the cross-lagged analysis, and the results showed that RC increase preceded the development of hypertension, rather than vice versa. Conclusions: RC had an unexpected high correlation with the prevalence and incidence of hypertension. Moreover, RC increase might precede the development of hypertension, suggesting the potential role of RC in the development of hypertension.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.