Evidence map›Paper›PMID 35222805›Full record

ArticleOxidative medicine and cellular longevity2022

The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury.

Wei Tang, Weina Chai, Donglin Du, Yongzhi Xia, Yifan Wu, Li Jiang, Chongjie Cheng, Zongduo Guo, Xiaochuan Sun, Zhijian Huang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wei TangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-2665-7460
Weina ChaiDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0001-9707-0598
Donglin DuDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0001-5748-3427
Yongzhi XiaDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-2948-0568
Yifan WuDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-6179-0494
Li JiangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-2407-3672
Chongjie ChengDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-0680-2448
Zongduo GuoDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-3415-9293
Xiaochuan SunDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-0666-9886
Zhijian HuangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-8241-0761
Jianjun ZhongDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 400016.ORCID https://orcid.org/0000-0002-9481-5088
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously discovered that traumatic brain injury (TBI) induces significant perturbations in long noncoding RNA (lncRNA) levels in the mouse cerebral cortex, and lncRNA-AK046375 is one of the most significantly changed lncRNAs after TBI. lncRNA-AK046375 overexpression and knockdown models were successfully constructed both

Indexed as

AnimalsApoptosisAstrocytesBlood-Brain BarrierBrainBrain Injuries, TraumaticCells, CulturedHydrogen PeroxideMetallothioneinMiceMice, Inbred C57BLMicroRNAsNeuronsNeuroprotective AgentsOxidative StressRNA, Long NoncodingHydrogen PeroxideMetallothioneinMicroRNAsMIRN491 microRNA, mouseMt2 protein, mouseNeuroprotective AgentsRNA, Long Noncoding

Identifiers

PMID35222805
PMCPMC8865981
OpenAlexW4213118615

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.