Evidence map›Paper›PMID 35225904›Full record

ArticleJournal of functional morphology and kinesiology2022

Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults.

Jinhyun Lee, Richard K Shields

Abstract read
In one paragraph

Article in Journal of functional morphology and kinesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Relationship between body water distribution and sarcopenia in older adults: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Review
  2. Article
  3. Article
  4. Special Issue "Role of Exercises in Musculoskeletal Disorders-4th Edition".Journal of functional morphology and kinesiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jinhyun LeeDepartment of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.
Richard K ShieldsDepartment of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

Funding

Long Duration Activity and Metabolic Control after Spinal Cord InjuryR01HD082109 · NICHD · UNIVERSITY OF IOWA · PI SHIELDS, RICHARD K. · 2015 to 2019
$1.6M
Musculoskeletal Plasticity after Spinal Cord InjuryR01HD084645 · NICHD · UNIVERSITY OF IOWA · PI SHIELDS, RICHARD K. · 2015 to 2019
$1.6M
NICHD NIH HHS R01 HD082109NICHD NIH HHS R01 HD084645NIH HHS R01-HD082109NIH HHS R01-HD084645
6 · The paper itself

Abstract

Compromised cognitive function is associated with increased mortality and increased healthcare costs. Physical characteristics including height, weight, body mass index, sex, and fat mass are often associated with cognitive function. Extracellular to intracellular body water ratio offers an additional anthropometric measurement that has received recent attention because of its association with systemic inflammation, hypertension, and blood−brain barrier permeability. The purposes of this study were to determine whether extracellular to intracellular body water ratios are different between younger and older people and whether they are associated with cognitive function, including executive function and attention, working memory, and information processing speed. A total of 118 healthy people (39 older; 79 younger) participated in this study. We discovered that extracellular to intracellular body water ratio increased with age, was predictive of an older person’s ability to inhibit information and stay attentive to a desired task (Flanker test; R2 = 0.24; p < 0.001), and had strong sensitivity (83%) and specificity (91%) to detect a lower executive function score. These findings support that extracellular to intracellular body water ratio offers predictive capabilities of cognitive function, even in a healthy group of elderly people.

Indexed as

agingblood–brain barrierbody compositioncognitive functioninflammation

Identifiers

PMID35225904
PMCPMC8883954

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.