Evidence map›Paper›PMID 35227220›Full record

ArticleBMC ophthalmology2022

The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus.

Rajya L Gurung, Liesel M FitzGerald, Ebony Liu, Bennet J McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W Hewitt, Brendan Jt Vote, Nitin Verma, Jamie E Craig and 1 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rajya L GurungMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia. rajyalaxmi.gurung@utas.edu.au.ORCID http://orcid.org/0000-0003-0816-9823
Liesel M FitzGeraldMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
Ebony LiuDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
Bennet J McComishMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
Georgia KaidonisDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
Bronwyn RidgeDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
Alex W HewittMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
Brendan Jt VoteSchool of Medicine, University of Tasmania, Hobart, TAS, Australia.
Nitin VermaSchool of Medicine, University of Tasmania, Hobart, TAS, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
University of Tasmania · AUFlinders University · AU

Funding

National Health and Medical Research Council (NHMRC) Australia Centre for Research Excellence GNT1116360
6 · The paper itself

Abstract

objectivesTo assess whether insulin therapy impacts the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of diabetic macular edema (DME) in type 2 diabetes mellitus.

methodsThis was a retrospective multi-center analysis. The best-corrected visual acuity (BCVA) at 12 months, BCVA change, central macular thickness (CMT), CMT change, and cumulative injection number were compared between the insulin and the oral hypoglycemic agent (OHA) groups.

resultsThe mean final BCVA and CMT improved in both the insulin (N = 137; p < 0.001; p < 0.001, respectively) and the OHA group (N = 61; p = 0.199; p < 0.001, respectively). The two treatment groups were comparable for final BCVA (p = 0.263), BCVA change (p = 0.184), final CMT (p = 0.741), CMT change (p = 0.458), and the cumulative injections received (p = 0.594). The results were comparable between the two groups when stratified by baseline vision (p > 0.05) and baseline HbA1c (p > 0.05).

conclusionInsulin therapy does not alter treatment outcomes for anti-VEGF therapy in DME.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyMacular EdemaAngiogenesis InhibitorsHumansInsulinIntravitreal InjectionsRetrospective StudiesTreatment OutcomeVisual AcuityAngiogenesis InhibitorsInsulinAnti-VEGFCentral macular thicknessDiabetic macular edemaInsulinVisual acuity

Identifiers

PMID35227220
PMCPMC8883612
OpenAlexW4214577189

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.