ReviewChild and adolescent psychiatry and mental health2022
Systematic review and meta-analysis of the effects of exercise on depression in adolescents.
Review in Child and adolescent psychiatry and mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 19 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 19 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Comparative effectiveness and dose-response relationships of exercise for depressive symptoms in children and adolescents: a Bayesian network meta-analysis.BMC psychiatry · 2026Pooled it
- The Effects of Physical Activity Intervention on Depression Symptoms in Children and Adolescents: A Meta-analysis of Randomized Controlled Trials.International journal of behavioral medicine · 2026Pooled it
- Virtual reality-based exercise interventions for the treatment of depression: a systematic review and meta-analysis of randomized controlled trials.BMC psychiatry · 2026Pooled it
- Physical activity modalities and dosing for postpartum depression, anxiety and quality of life: a network meta-analysis and dose response of randomized trials.BMC public health · 2026Pooled it
- Effects of exercise on cognitive function in patients with depression: a three-level meta-analysis with dose-response and exploratory mediation analyses.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Aerobic exercise for depression symptoms in adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2026Pooled it
- Impact of Structured Physical Exercise on Adolescent Depression: A Comprehensive Meta-Analysis of RCTs.CNS & neurological disorders drug targets · 2026Pooled it
- Pooled it
- Effect of exercise interventions on depression, anxiety, and self-esteem in children and adolescents: a systematic review and network meta-analysis.BMC public health · 2025Pooled it
- Effectiveness of different therapeutic measures combined with aerobic exercise as an intervention in patients with depression: a systematic review and network meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis.Frontiers in psychology · 2025Pooled it
- A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression.PloS one · 2025Pooled it
- Effects of urban green exercise on mental health: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Effectiveness of exercise intervention on children and adolescents with depression: a systematic review and meta-analysis of randomized controlled trial.Frontiers in psychiatry · 2025Pooled it
- Pooled it
- The effect of the physical exercise intervention on negative emotions in children and adolescents with neurodevelopmental disorders: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Effects of exercise on depression in patients with rheumatic diseases: a systematic review and meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- The influence of physical exercise on negative emotions in adolescents: a meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Exercise intervention and improvement of negative emotions in children: a meta-analysis.BMC pediatrics · 2023Pooled it
- Effects of Urban Forest Therapy Program on Depression Patients.International journal of environmental research and public health · 2022Trial
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDepression is widespread among adolescents and seriously endangers their quality of life and academic performance. Developing strategies for adolescent depression has important public health implications. No systematic review on the effectiveness of physical exercise for adolescents aged 12-18 years with depression or depressive symptoms has previously been conducted. This study aims to systematically evaluate the effect of physical exercise on adolescent depression in the hope of developing optimum physical exercise programs.
methodsNine major databases at home and abroad were searched to retrieve randomized controlled trials (RCTs) on exercise interventions among adolescents with depression or depressive symptoms. The retrieval period started from the founding date of each database to May 1, 2021. The methodological quality of the included articles was evaluated using the modified PEDro scale. A meta-analysis, subgroup analysis, sensitivity analysis, and publication bias tests were then conducted.
resultsFifteen articles, involving 19 comparisons, with a sample size of 1331, were included. Physical exercise significantly reduced adolescent depression (standardized mean difference [SMD] = - 0.64, 95% CI - 0.89, - 0.39, p < 0.01), with a moderate effect size, in both adolescents with depression (SMD = -0.57, 95% CI - 0.90, - 0.23, p < 0.01) and adolescents with depressive symptoms (SMD = - 0.67, 95% CI - 1.00, - 0.33, p < 0.01). In subgroups of different depression categories (depression or depressive symptoms), aerobic exercise was the main form of exercise for the treatment of adolescents with depression. For adolescents with depression, interventions lasting 6 weeks, 30 min/time, and 4 times/week had optimum results. The effects of aerobic exercise and resistance + aerobic exercise in the subgroup of adolescents with depressive symptoms were significant, while the effect of physical and mental exercise (yoga) was not significant. For adolescents with depressive symptoms, aerobic exercise lasting 8 weeks, 75-120 min/time, and 3 times/week had optimum results. Physical exercise with moderate intensity is a better choice for adolescents with depression and depressive symptoms.
conclusionsPhysical exercise has a positive effect on the improvement of depression in adolescents. The protocol for this study was registered with INPLASY (202170013). DOI number is 10.37766/inplasy2021.7.0013. Registration Date:2021.7.06.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.