ArticleBMC pregnancy and childbirth2022
Pre-pregnancy lifestyle characteristics and risk of miscarriage: the Australian Longitudinal Study on Women's Health.
Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Antenatal intervention for childbirth trauma: the clinical profile of Australian women at a tertiary hospital.BMC pregnancy and childbirth · 2026Article
- Longer commute time is associated with a higher risk of miscarriage: a mixed-effects longitudinal study.BMC pregnancy and childbirth · 2025Article
- Health professionals require more defined protocols, better funding and patient resources to support couples with recurrent pregnancy loss.Scientific reports · 2025Article
- Doing community involvement care-fully: using an ethic of care to guide involvement in research on women's health after pregnancy complications and loss.Research involvement and engagement · 2025Article
- Generational differences in associations between health conditions in young women and BMI categories.Obesity (Silver Spring, Md.) · 2025Article
- Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage.Science advances · 2025Article
- Risk factors for first-trimester spontaneous abortion and the role of preconception care.Frontiers in global women's health · 2025Article
- The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study.International journal of women's health · 2025Article
- Preconception and Early-Pregnancy Body Mass Index in Women and Men, Time to Pregnancy, and Risk of Miscarriage.JAMA network open · 2024Article
- Risk and protective factors of miscarriage: Evidence from a nationally representative sample of women in India.Journal of family medicine and primary care · 2024Article
- The effect of previous induced abortion history on the assisted reproduction outcomes.Archives of gynecology and obstetrics · 2024Article
- Polyploidy Phenomenon as a Cause of Early Miscarriages in Abortion Materials.Balkan journal of medical genetics : BJMG · 2023Article
- Review
- Adherence to Nordic dietary patterns and risk of first-trimester spontaneous abortion.European journal of nutrition · 2022Article
- Potential safety signal of pregnancy loss with vascular endothelial growth factor inhibitor intraocular injection: A disproportionality analysis using the Food and Drug Administration Adverse Event Reporting System.Frontiers in pharmacology · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies of lifestyle characteristics and risk of miscarriage have mostly been retrospective and failed to account for induced abortions. We examine whether pre-pregnancy body-mass index, alcohol intake and smoking influence the risk of miscarriage after accounting for induced abortions.
methodsWe conducted a prospective cohort study of 9213 women with 26,594 pregnancies participating in the Australian Longitudinal Study on Women's Health. We examined whether body-mass index, smoking and alcohol intake prior to pregnancy was associated with miscarriage. We estimated adjusted relative risks (RR) using generalized estimating equations with an exchangeable correlation matrix. We explored the impact of accounting for induced abortion by first excluding all induced abortions, and secondly including 50% of induced abortions in the comparison group.
resultsOf the 26,592 pregnancies which occurred during the follow-up period, 19% ended in a miscarriage. We observed an increased risk of miscarriage according to pre-pregnancy obesity compared to normal weight (adjusted RR 1.13; 95% CI 1.05, 1.21), smoking between 10 and 19 cigarettes per day compared to not smoking (adjusted RR 1.13; 95% CI 1.02, 1.25), but not smoking 20 or more cigarettes per day (adjusted RR 1.07; 95% CI 0.94, 1.21) and risky drinking (≥2 units per day; adjusted RR 1.15; 95% CI 1.03, 1.28) compared to low risk drinking (< 2 units per day). The results for smoking (adjusted RR 1.09 for 10-19 cigarettes per day; 95% CI 0.98, 1.21) was attenuated after including 50% of induced abortions in the comparison group.
conclusionsWe observed a modest increased risk of miscarriage according to obesity and risky alcohol intake prior to pregnancy. There was no evidence of a dose-response relationship with smoking, and the association between smoking and risk of miscarriage was attenuated after accounting for induced abortions.
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