ArticleThe New England journal of medicine1986
Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes.
Article in The New England journal of medicine, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 257 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Family Management of Childhood Diabetes Study
Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes
Who cites it
257 citing papers in PubMed, 8 syntheses or guidelines pooled it, 953 citations in OpenAlex.
- Prevalence of youth type 2 diabetes in global Indigenous populations: a systematic review.Diabetologia · 2026Pooled it
- Pooled it
- Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review.Paediatric drugs · 2024Pooled it
- Do sex differences in paediatric type 1 diabetes care exist? A systematic review.Diabetologia · 2023Pooled it
- Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta-analysis.Pediatric diabetes · 2019Pooled it
- Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus.The Cochrane database of systematic reviews · 2014Pooled it
- Low glycaemic index dietary interventions in youth with cystic fibrosis: a systematic review and discussion of the clinical implications.Nutrients · 2012Pooled it
- Interventions with adherence-promoting components in pediatric type 1 diabetes: meta-analysis of their impact on glycemic control.Diabetes care · 2010Pooled it
- Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2024Trial
- More hypoglycemia not associated with increasing estimated adiposity in youth with type 1 diabetes.Pediatric research · 2023Trial
- Two-Year Treatment With Metformin During Puberty Does Not Preserve β-Cell Function in Youth With Obesity.The Journal of clinical endocrinology and metabolism · 2021Trial
- Exercise capacity and cardiac function in adolescents born post-term.Scientific reports · 2018Trial
- Associations between major life events and adherence, glycemic control, and psychosocial characteristics in teens with type 1 diabetes.Pediatric diabetes · 2018Trial
- Reduction of hypoglycaemic events with a behavioural intervention: a randomized clinical trial for paediatric patients with Type 1 diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2017Trial
- Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?Nutrition (Burbank, Los Angeles County, Calif.) · 2017Trial
- A model of parental distress and factors that mediate its link with parental monitoring of youth diabetes care, adherence, and glycemic control.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016Trial
- Trial
- Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial.Diabetologia · 2016Trial
- Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study.PloS one · 2016Trial
- Efficacy of a Behavioral Intervention for Pediatric Type 1 Diabetes Across Income.American journal of preventive medicine · 2015Trial
197 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Patients with insulin-dependent diabetes mellitus often have poor metabolic control during puberty. To determine whether puberty is associated with decreased insulin-stimulated glucose metabolism, we compared the results of euglycemic insulin-clamp studies in adults and prepubertal and pubertal children with and without insulin-dependent diabetes. In nondiabetic pubertal children, insulin-stimulated glucose metabolism (201 +/- 12 mg per square meter of body surface area per minute) was sharply reduced, as compared with that of prepubertal children and adults (316 +/- 34 and 290 +/- 21 mg per square meter, respectively; P less than 0.01), despite comparable hyperinsulinemia (insulin levels of 80 to 90 microU per milliliter). Similarly, the response to insulin was 25 to 30 percent lower in the diabetic pubertal children than in the diabetic prepubertal children (P less than 0.05) and adults (P = 0.07). At each stage of development, the stimulating effect of insulin on glucose metabolism was decreased by 33 to 42 percent in the children with diabetes (P less than 0.01). In all the groups of children studied, the response to insulin was inversely correlated with mean 24-hour levels of growth hormone (r = -0.52, P = 0.01). Among the diabetic children, the glycosylated hemoglobin levels were substantially higher in the pubertal children than in the prepubertal children (P less than 0.02), although the daily insulin doses tended to be higher. These data suggest that insulin resistance occurs during puberty in both normal children and children with diabetes. The combined adverse effects of puberty and diabetes on insulin action may help explain why control of glycemia is so difficult to achieve in adolescent patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.