Evidence mapPaperPMID 35233724Full record

Trial reportThe international journal of cardiovascular imaging2022

The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study.

Aseel Alfuhied, Gaurav S Gulsin, Lavanya Athithan, Emer M Brady, Kelly Parke, Joseph Henson, Emma Redman, Anna-Marie Marsh, Thomas Yates, Melanie J Davies and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Glycemic status and left atrial structure and function in adults with metabolic syndrome and overweight-obesity.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Aseel AlfuhiedDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Lavanya AthithanDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Emer M BradyDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Kelly ParkeDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Joseph HensonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Emma RedmanDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Anna-Marie MarshDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Thomas YatesDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Melanie J DaviesDiabetes Research Centre, NIHR Leicester Biomedical Research Centre, Leicester, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Anvesha SinghDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK. as707@leicester.ac.uk.ORCID http://orcid.org/0000-0003-1112-3973
University of Leicester · GBNIHR Leicester Biomedical Research Centre · GB

Funding

National Institute for Health Research CDF 2014-07-045
6 · The paper itself

Abstract

Aerobic exercise training and low energy diets have been shown to improve left ventricular remodelling and diastolic function in adults with type 2 diabetes (T2D), albeit with differential effects. The impact of these lifestyle interventions on left atrial (LA) function, however, has not previously been reported. The DIASTOLIC study was a prospective, randomised, open-label, blind endpoint trial, in which 90 people with obesity and T2D and no prevalent cardiovascular disease were randomised to a 12-week intervention of: (i) routine care, (ii) aerobic exercise training, or (iii) low energy (≈ 810 kcal/day) meal replacement plan (MRP). Cardiac magnetic resonance (CMR) imaging was performed pre- and post-intervention. Image analysis included LA volumes (LAV), emptying fraction (LAEF), and LA strain (LAS) corresponding to LA reservoir (LAS-r), conduit (LAS-cd), and booster pump (LAS-bp) function. 73 participants with T2D (mean age 50 ± 6 years, 62% male, body mass index (BMI) 36.1 ± 5.3 kg/m

Indexed as

Diabetes Mellitus, Type 2AdultAtrial Function, LeftFemaleHeart AtriaHumansLife StyleMaleMiddle AgedObesityPredictive Value of TestsProspective StudiesCardiac magnetic resonance imagingLeft atriumLifestyleType 2 diabetes

Identifiers

PMID35233724
PMCPMC10247829
OpenAlexW4214939218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.