ArticleScience advances2022
Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- Multivariate GWAS framework for family trios with parental phenotypes to control dynastic effects.BMC bioinformatics · 2026Article
- The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases.Genetic epidemiology · 2026Article
- METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Briefings in bioinformatics · 2026Article
- Bidirectional and mediation Mendelian randomization of dietary intake and risks of gastric ulcer and gastric cancer.Medicine · 2026Article
- Towards improved fine-mapping of candidate causal variants.Nature reviews. Genetics · 2025Review
- Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects.American journal of human genetics · 2025Article
- Association between keloid and mental disorders: perspective from genetic evidence.Annals of general psychiatry · 2025Article
- Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- A multivariable cis-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias.Briefings in bioinformatics · 2025Article
- Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies.Nature communications · 2025Article
- A robust and powerful GWAS method for family trios supporting within-family Mendelian randomization analysis.Research square · 2025Article
- Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study.BMC medicine · 2025Article
- MR-SPLIT: A novel method to address selection and weak instrument bias in one-sample Mendelian randomization studies.PLoS genetics · 2024Article
- Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics.American journal of human genetics · 2024Article
- MRBEE: A bias-corrected multivariable Mendelian randomization method.HGG advances · 2024Article
- A robust cis-Mendelian randomization method with application to drug target discovery.Nature communications · 2024Article
- simmrd: An open-source tool to perform simulations in Mendelian randomization.Genetic epidemiology · 2024Article
- CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.Cancer research · 2024Article
- Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.Translational psychiatry · 2024Article
- An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.PLoS genetics · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Mendelian randomization (MR) is a common tool for identifying causal risk factors underlying diseases. Here, we present a method, MR with automated instrument determination (MRAID), for effective MR analysis. MRAID borrows ideas from fine-mapping analysis to model an initial set of candidate single-nucleotide polymorphisms that are in potentially high linkage disequilibrium with each other and automatically selects among them the suitable instruments for causal inference. MRAID also explicitly models both uncorrelated and correlated horizontal pleiotropic effects that are widespread for complex trait analysis. MRAID achieves both tasks through a joint likelihood framework and relies on a scalable sampling-based algorithm to compute calibrated
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.