Evidence map›Paper›PMID 35238622›Full record

ArticleCirculation. Arrhythmia and electrophysiology2022

Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.

Kedar Aras, Anna Gams, Ndeye Rokhaya Faye, Jaclyn Brennan, Katherine Goldrick, Jinghua Li, Yishan Zhong, Chia-Han Chiang, Elizabeth H Smith, Megan D Poston and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Abnormal CaFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Kedar ArasDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0002-9898-1462
Anna GamsDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0002-3052-8469
Ndeye Rokhaya FayeDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0001-5695-7838
Jaclyn BrennanDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0002-0757-546X
Katherine GoldrickDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0002-2956-4606
Jinghua LiDepartment of Biomedical Engineering, Northwestern University, Evanston, IL (J.L., J.A.R.).
Yishan ZhongDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign (Y.Z.).ORCID 0000-0002-7010-4521
Chia-Han ChiangDepartment of Biomedical Engineering, Duke University, Durham, NC (C.-H.C., J.V.).
Elizabeth H SmithDepartment of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).ORCID 0000-0001-6037-2322
Megan D PostonDepartment of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).ORCID 0000-0002-4842-7295
Jacqueline ChiversDepartment of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).
Peter HannaUniversity of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).ORCID 0000-0003-3092-5090
Shumpei MoriUniversity of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).ORCID 0000-0002-5803-7135
Olujimi A AjijolaUniversity of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).ORCID 0000-0001-6197-7593
Kalyanam ShivkumarUniversity of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).ORCID 0000-0002-4121-1766
Donald B HooverDepartment of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).ORCID 0000-0002-0845-2488
Jonathan ViventiDepartment of Biomedical Engineering, Duke University, Durham, NC (C.-H.C., J.V.).ORCID 0000-0001-6054-0541
John A RogersDepartment of Biomedical Engineering, Northwestern University, Evanston, IL (J.L., J.A.R.).ORCID 0000-0002-2980-3961
Olivier BernusInstitut de rhythmologie et de modélisation cardiaque (LIRYC; The Rhythmology and Heart Modeling Institute), Bordeaux University, France (N.R.F., O.B.).ORCID 0000-0003-3917-5791
Igor R EfimovDepartment of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).ORCID 0000-0002-1483-5039
George Washington University · USEast Tennessee State University · USUniversity of California, Los Angeles · USDuke University · USNorthwestern University · USElectrophysiology and Heart Modeling Institute · FRUniversity of Illinois Urbana-Champaign · US

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
HLS-Cardiac Safety AI Trained Human Heart and Micro Heart ModelR44HL139248 · NHLBI · INVIVOSCIENCES, INC. · PI WAKATSUKI, TETSURO · 2018 to 2020
$2.1M
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human heartsK99HL148523 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI ARAS, KEDAR KIRTIKUMAR · 2020 to 2021
$198k
The First Step toward a Neuronal Pacemaker of the HeartF32HL152609 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HANNA, PETER · 2020 to 2020
$80k
NHLBI NIH HHS F32 HL152609NHLBI NIH HHS K99 HL148523NHLBI NIH HHS R44 HL139248NIH HHS OT2 OD023848
6 · The paper itself

Abstract

backgroundRight ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of detailed electrophysiological and molecular studies of the human RVOT.

methodsWe conducted optical mapping studies in 16 nondiseased donor human RVOT preparations subjected to pharmacologically induced adrenergic and cholinergic stimulation to evaluate susceptibility to arrhythmias and characterize arrhythmia dynamics.

resultsWe found that under control conditions, RVOT has shorter action potential duration at 80% repolarization relative to the right ventricular apical region. Treatment with isoproterenol (100 nM) shortened action potential duration at 80% repolarization and increased incidence of premature ventricular contractions (

conclusionsHuman RVOT electrophysiology is characterized by shorter action potential duration relative to the right ventricular apical region. Cholinergic right ventricular stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of premature ventricular contractions and shortening of wavelength. Right ventricular arrhythmia is characterized by positive spatial-temporal autocorrelation between epicardial-endocardial arrhythmic wave fronts and rotors that are relatively more organized in the endocardium.

Indexed as

Tachycardia, VentricularVentricular Premature ComplexesAcetylcholineAdrenergic AgentsCardiac ElectrophysiologyCholinergic AgentsElectrocardiographyFemaleHeart VentriclesHuman RightsHumansIsoproterenolMalePericardiumAcetylcholineAdrenergic AgentsCholinergic AgentsIsoproterenolacetylcholinearrhythmias, cardiacheart ventriclesisoproterenolventricular premature complexes

Identifiers

PMID35238622
PMCPMC9052172
OpenAlexW4214891470

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.