Evidence map›Paper›PMID 35239443›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Discovery of a functionally selective ghrelin receptor (GHSR

J D Gross, D W Kim, Y Zhou, D Jansen, L M Slosky, N B Clark, C R Ray, X Hu, N Southall, A Wang and 8 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. GPCR Biased Signaling in Metabolism.Handbook of experimental pharmacology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Ghrelin receptor signaling in health and disease: a biased view.Trends in endocrinology and metabolism: TEM · 2023
    Review
  9. In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

J D GrossDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-0925-6331
D W KimNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
Y ZhouDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
D JansenNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
L M SloskyDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-9471-9117
N B ClarkDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
C R RayDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
X HuNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
N SouthallNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.ORCID 0000-0003-4500-880X
A WangNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
X XuNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
E BarnaevaNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
W C WetselDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-3592-7397
M FerrerNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.
J J MaruganNational Center for Advancing Translational Sciences, NIH Division of Preclinical Innovation, Rockville, MD 20892.ORCID 0000-0002-3951-7061
M G CaronDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
L S BarakDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-9170-2141
K TothDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-6590-6394
Duke University · USNational Center for Advancing Translational Sciences · US

Funding

Pharmacokinetics and Drug MetabolismZIATR000369 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XU, XIN · 2018 to 2025
$27.3M
Akt/GSK-3 Signaling Cascade and the Actions of DopamineR37MH073853 · NIMH · DUKE UNIVERSITY · PI CARON, MARC G. · 2011 to 2020
$6.4M
Science PlanP30DA029925 · NIDA · DUKE UNIVERSITY · PI CARON, MARC G. · 2010 to 2018
$6.2M
Identification of small molecule that selectively modulate Ghrelin receptor (GHSR1a) b-arrestin signaling as a new therapeutic approach for the treatment of addictionZIATR000083 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI MARUGAN, JUAN · 2015 to 2025
$2.9M
Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of AddictionR00DA048970 · NIDA · UNIVERSITY OF MINNESOTA · PI SLOSKY, LAUREN M · 2022 to 2024
$747k
A novel functionally selective drug for the treatment of cocaine abuse by antagonism of the beta-arrestin signaling arm of the Ghrelin ReceptorU18DA052417 · NIDA · DUKE UNIVERSITY · PI BARAK, LAWRENCE S. · 2020 to 2020
$242k
Exploiting Biased Agonism at the Ghrelin Receptor (GHSR1a) for Opioid AddictionF32DA051139 · NIDA · DUKE UNIVERSITY · PI GROSS, JOSHUA D · 2020 to 2022
$201k
Intramural NIH HHS ZIA TR000083NIDA NIH HHS F32 DA051139NIDA NIH HHS P30 DA029925NIDA NIH HHS R00 DA048970NIDA NIH HHS U18 DA052417NIMH NIH HHS R37 MH073853
6 · The paper itself

Abstract

SignificanceThe modulation of growth hormone secretagogue receptor-1a (GHSR

Indexed as

AnimalsBrainDopamineGTP-Binding Protein alpha Subunits, Gq-G11MaleMiceMice, KnockoutReceptors, GhrelinDopamineGhsr protein, MouseGTP-Binding Protein alpha Subunits, Gq-G11Receptors, Ghrelindopaminefunctional selectivityghrelinGPCRNCATS-SM8864

Identifiers

PMID35239443
PMCPMC8915830
OpenAlexW4214926949

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.