Evidence map›Paper›PMID 35241503›Full record

ArticleNeurology2022

Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults.

Andrea R Zammit, Lei Yu, Vladislav Petyuk, Julie A Schneider, Philip Lawrence De Jager, Hans-Ulrich Klein, David A Bennett, Aron S Buchman

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Proteome-wide association study of cortical proteins that may provide resilience for late-life disability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  18. Correlated decline of cognitive and motor phenotypes and ADRD pathologies in old age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea R ZammitFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY. andrea_r_zammit@rush.edu.
Lei YuFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.ORCID 0000-0002-7176-1152
Vladislav PetyukFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.ORCID 0000-0003-4076-151X
Julie A SchneiderFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.
Philip Lawrence De JagerFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.ORCID 0000-0002-8057-2505
Hans-Ulrich KleinFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.
David A BennettFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.
Aron S BuchmanFrom the Rush Alzheimer's Disease Center (A.R.Z., Y.L., J.A.S., D.A.B., A.S.B.), Department of Psychiatry and Behavioral Sciences (A.R.Z.), Department of Neurological Sciences (Y.L., J.A.S., D.A.B., A.S.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Biological Sciences Division (V.P.), Pacific Northwest National Laboratory, Richland, WA; and Center for Translational & Computational Neuroimmunology (P.L.D.J., H.-U.K.), Department of Neurology, Columbia University Medical Center, New York, NY.
Rush University Medical Center · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Elucidating the molecular drivers of impaired mobility within and outside the CNS in Alzheimer’s disease and related disordersR01AG059732 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2019 to 2023
$2.8M
Spinal cord and brainstem pathology contributions to late-life gait impairmentR01AG047976 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2015 to 2019
$2.6M
Application of latent and integrative approaches to understand the spectrum of cognitive agingK01AG054700 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ZAMMIT, ANDREA ROSE · 2017 to 2021
$653k
NIA NIH HHS K01 AG054700NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG047976NIA NIH HHS R01 AG059732NIA NIH HHS U01 AG061356
6 · The paper itself

Abstract

BACKGROUND AND

objectivesCognitive resilience is a well-recognized concept, but knowledge gaps about its underlying mechanisms have made it difficult to develop instruments that identify older adults with high or low resilience. We tested whether aggregating cortical peptides associated with cognitive resilience into an index can identify adults with higher or lower cognitive resilience.

methodsWe used data from 1,192 older decedents, including annual clinical testing, indices of 10 Alzheimer disease (AD) and related dementia (ADRD) pathologies, and 226 proteotypic peptides measured in the dorsal lateral prefrontal cortex. We used linear mixed-effects models to identify peptides that were related to cognitive resilience (i.e., cognitive decline not explained by ADRD pathologies [false discovery rate <0.05]). We aggregated the expression levels of these resilience peptides into a person-specific cognitive resilience index and examined its association with AD clinical and pathologic phenotypes.

resultsWe constructed a resilience index from 52 of 226 peptides related to cognitive resilience. A higher index was associated with slower cognitive decline (estimate 0.05, SE 0.003, DISCUSSION: Cortical proteins may provide some degree of cognitive resilience. These multifunctional proteins also seem to provide resilience to other AD clinical phenotypes and have independent associations with ADRD pathologies. Resilience proteins may be high-value therapeutic targets for drug discovery of interventions that maintain brain health in aging adults via multiple pathways.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedBrainCognitionHumansIndividuality

Identifiers

PMID35241503
PMCPMC8967427
OpenAlexW4214816779

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.