Evidence map›Paper›PMID 35241789›Full record

ArticleCommunications biology2022

Chromosome-scale Echinococcus granulosus (genotype G1) genome reveals the Eg95 gene family and conservation of the EG95-vaccine molecule.

Pasi K Korhonen, Liina Kinkar, Neil D Young, Huimin Cai, Marshall W Lightowlers, Charles Gauci, Abdul Jabbar, Bill C H Chang, Tao Wang, Andreas Hofmann and 25 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 16 institutions in 12 countries.

Pasi K Korhonen *Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-9957-4674
Liina Kinkar *Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Neil D YoungDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0001-8756-229X
Huimin CaiBGI-Shenzhen, Shenzhen, 518083, China.
Marshall W LightowlersDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Charles GauciDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0001-5097-2164
Abdul JabbarDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Bill C H ChangDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0001-5313-4852
Tao WangDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Andreas HofmannDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Anson V KoehlerDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Junhua LiBGI-Shenzhen, Shenzhen, 518083, China.ORCID http://orcid.org/0000-0001-6784-1873
Jiandong LiBGI-Shenzhen, Shenzhen, 518083, China.
Daxi WangBGI-Shenzhen, Shenzhen, 518083, China.
Jiefang YinBGI-Shenzhen, Shenzhen, 518083, China.
Huanming YangBGI-Shenzhen, Shenzhen, 518083, China.
David J JenkinsSchool of Animal and Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW, 2678, Australia.
Urmas SaarmaDepartment of Zoology, Institute of Ecology and Earth Sciences, University of Tartu, J. Liivi 2, Tartu, 50409, Estonia.
Teivi LaurimäeDepartment of Zoology, Institute of Ecology and Earth Sciences, University of Tartu, J. Liivi 2, Tartu, 50409, Estonia.
Mohammad Rostami-NejadGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Malik IrshadullahSection of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, 202002, India.
Hossein MirhendiDepartment of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mitra SharbatkhoriLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.ORCID http://orcid.org/0000-0002-1896-9317
Francisco Ponce-GordoDepartment of Parasitology, Faculty of Pharmacy, Complutense University, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0001-9034-8606
Sami SimsekDepartment of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Turkey.
Adriano CasulliWorld Health Organization Collaborating Centre for the Epidemiology, Detection and Control of Cystic and Alveolar Echinococcosis, European Union Reference Laboratory for Parasites (EURLP), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.ORCID http://orcid.org/0000-0001-9183-7591
Houria ZaitParasitology and Mycology Department, Mustapha University Hospital, 16000, Algiers, Algeria.ORCID http://orcid.org/0000-0003-3980-1393
Hripsime AtoyanYerevan State University, Department of Zoology, Alex Manoogian, Yerevan, 0025, Armenia.
Mario Luiz de la RueUniversidade Federal de Santa Maria, Departamento de Microbiologia e Parasitologia, Santa Maria, RS, Brazil.
Thomas RomigInstitute of Zoology, Parasitology Unit, University of Hohenheim, 70599, Stuttgart, Germany.
Marion WassermannInstitute of Zoology, Parasitology Unit, University of Hohenheim, 70599, Stuttgart, Germany.
Sargis A AghayanChair of Zoology, Yerevan State University, 1 Alex Manoogian, Yerevan, 0025, Armenia.
Hasmik GevorgyanMolecular Parasitology Research Group, Scientific Center - Zoology and Hydroecology, 7P. Sevak str, Yerevan, 0014, Armenia.
Bicheng YangBGI Australia, Oceania, BGI Group, CBCRB Building, Herston Road, Herston, QLD, 4006, Australia.
Robin B GasserDepartment of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. robinbg@unimelb.edu.au.ORCID http://orcid.org/0000-0002-4423-1690
The University of Melbourne · AUBGI Group (China) · CNUniversity of Hohenheim · DEUniversity of Tartu · EEYerevan State University · AMAligarh Muslim University · INCharles Sturt University · AUFırat University · TRGolestan University · IRHôpital Mustapha Pacha · DZIsfahan University of Medical Sciences · IRIstituto Superiore di Sanità · ITScientific Center of Zoology and Hydroecology · AMShahid Beheshti University of Medical Sciences · IRUniversidad Complutense de Madrid · ESUniversidade Federal de Santa Maria · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic echinococcosis is a socioeconomically important parasitic disease caused by the larval stage of the canid tapeworm Echinococcus granulosus, afflicting millions of humans and animals worldwide. The development of a vaccine (called EG95) has been the most notable translational advance in the fight against this disease in animals. However, almost nothing is known about the genomic organisation/location of the family of genes encoding EG95 and related molecules, the extent of their conservation or their functions. The lack of a complete reference genome for E. granulosus genotype G1 has been a major obstacle to addressing these areas. Here, we assembled a chromosomal-scale genome for this genotype by scaffolding to a high quality genome for the congener E. multilocularis, localised Eg95 gene family members in this genome, and evaluated the conservation of the EG95 vaccine molecule. These results have marked implications for future explorations of aspects such as developmentally-regulated gene transcription/expression (using replicate samples) for all E. granulosus stages; structural and functional roles of non-coding genome regions; molecular 'cross-talk' between oncosphere and the immune system; and defining the precise function(s) of EG95. Applied aspects should include developing improved tools for the diagnosis and chemotherapy of cystic echinococcosis of humans.

Indexed as

EchinococcosisEchinococcus granulosusVaccinesAnimalsAntigens, HelminthChromosomesGenotypeHelminth ProteinsAntigens, HelminthHelminth ProteinsVaccines

Identifiers

PMID35241789
PMCPMC8894454
OpenAlexW4214951828

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.