SynthesisAndrologia2022
The association of impaired semen quality and pregnancy rates in assisted reproduction technology cycles: Systematic review and meta-analysis.
Synthesis in Andrologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Surgical efficacy and predictors of outcome in varicocelectomy: a meta-analysis of multivariable studies.World journal of urology · 2025Pooled it
- The Effect of Endurance Exercise on Semen Quality in Male Athletes: A Systematic Review.Sports medicine - open · 2024Pooled it
- The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis.Asian journal of andrology · 2023Pooled it
- The association of impaired semen quality and pregnancy rates in assisted reproduction technology cycles: Systematic review and meta-analysis.Andrologia · 2022Pooled it
- Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study.Reproductive biology and endocrinology : RB&E · 2025Trial
- Intracytoplasmic Sperm Injection Clinical Outcomes: A Non-Inferiority Comparison of The Novel Felix™ Electrophoretic System and Conventional Density Gradient Centrifugation for Sperm Selection, A Prospective Clinical Trial.International journal of fertility & sterility · 2026Article
- Evaluating Sperm DNA Damage: When and Why It Adds to the Management of the Infertile Man.Advances in experimental medicine and biology · 2026Review
- Factors associated withFrontiers in endocrinology · 2026Article
- The influence of ambient air pollution during folliculogenesis, endometrial development, and spermatogenesis on fertility: A study among patients using vitrified donor oocyte in vitro fertilization.Environmental research · 2025Article
- Semen Characteristics and Embryo Outcomes in IVF.Journal of family & reproductive health · 2025Article
- The role of granulocyte-macrophage colony-stimulating factor in inducing autophagy in the spermatozoa of patients with asthenoteratozoospermia.Clinical and experimental reproductive medicine · 2025Article
- Impact of Shorter Abstinence Periods on Semen Parameters: A Systematic Review and Meta-Analysis.The world journal of men's health · 2025Article
- Impact of Male Age and Semen Parameters on Blastocyst Morphology, Beta-HCG Positivity and Pregnancy Viability: A Retrospective Analysis in Frozen Embryo Transfer Cycles.Journal of obstetrics and gynaecology of India · 2025Article
- In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects.JCI insight · 2025Article
- Artificial intelligence model for the assessment of unstained live sperm morphology.Reproduction & fertility · 2025Article
- First clinical pregnancy and delivery achieved after using a new 3D imaging technology for sperm selection: a case report.Frontiers in reproductive health · 2025Article
- Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality.Environment international · 2024Article
- Article
- Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies.Genomics, proteomics & bioinformatics · 2024Review
- Stain-Free Sperm Analysis and Selection for Intracytoplasmic Sperm Injection Complying with WHO Strict Normal Criteria.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Some studies suggest a relationship between semen quality and pregnancy rates of assisted reproduction technologies (ART). Others have questioned the utility of semen quality as proxy for fertility in couples attempting to conceive with or without assistance. We aimed to investigate the current body of evidence which correlates semen parameters and clinical pregnancy among couples utilizing ART (i.e. in vitro fertilization [IVF], intracytoplasmic sperm injection [ICSI]) through a systematic review and meta-analysis of cross-sectional and retrospective cohort studies. Pooled Odd Ratio (OR) for oligo-, astheno- and teratospermic compared to normospermic number of ART cycles were calculated among. Meta-regression and sub-group analysis were implemented to model the contribution of clinical/demographic and laboratory standards differences among the studies. Overall, 17 studies were analysed representing 17,348 cycles were analysed. Pooled OR for impaired sperm concentration, motility and morphology was 1 (95%Confidence Interval [CI]: 0.97-1.03), 0.88 (95%CI: 0.73-1.03) and 0.88 (95%CI: 0.75-1) respectively. Further analysis on sperm morphology showed no differences with regard of IVF versus ICSI (p = 0.14) nor a significant correlation with rising reference thresholds (Coeff: -0.02, p = 0.38). A temporal trend towards a null association between semen parameters and clinical pregnancy was observed over the 20-year observation period (Coeff: 0.01, p = 0.014). The current analysis found no association between semen quality (as measured by concentration, motility or morphology) and clinical pregnancy rates utilizing ART. Future investigations are necessary to explore the association between semen parameters and other ART outcomes (e.g. fertilization, implantation, birth and perinatal health).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.