Evidence map›Paper›PMID 35245406›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

"Exceptions that prove the rule"-Why have clinical trials failed to show efficacy of risk factor interventions suggested by observational studies of the dementia-Alzheimer's disease syndrome?

John C S Breitner, Hiroko H Dodge, Zaven S Khachaturian, Ara S Khachaturian

Abstract readEditorial
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Perspective: Emerging challenges for a future ADNI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Review
  4. Review
  5. Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  6. Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John C S BreitnerDouglas Hospital Research Center and McGill University, Montreal, Quebec, Canada.
Hiroko H DodgeDepartment of Neurology, Oregon Health & Science University, Portland, Oregon, USA.
Zaven S KhachaturianAlzheimer's & Dementia: The Journal of the Alzheimer's Association, Rockville, Maryland, USA.
Ara S KhachaturianAlzheimer's & Dementia: The Journal of the Alzheimer's Association, Rockville, Maryland, USA.

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Conversational Engagement as a Means to Delay Onset AD: Phase II Administrative SupplementR01AG051628 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 2016 to 2020
$4.8M
Web-enabled social interaction to delay cognitive decline among seniors with MCI: Phase I Administrative SupplementR01AG056102 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI SILBERT, LISA C · 2017 to 2021
$4.6M
NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG051628NIA NIH HHS R01 AG056102
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseHumansRisk Factors

Identifiers

PMID35245406
PMCPMC8940699

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.