Evidence map›Paper›PMID 35248086›Full record

ReviewChinese medicine2022

The application of mass spectrometry imaging in traditional Chinese medicine: a review.

Lieyan Huang, Lixing Nie, Zhong Dai, Jing Dong, Xiaofei Jia, Xuexin Yang, Lingwen Yao, Shuang-Cheng Ma

Open access · goldAbstract readReview
In one paragraph

Review in Chinese medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Spatial Metabolomics and Its Application in Plant Research.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lieyan Huang *National Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China.
Lixing Nie *National Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China.ORCID http://orcid.org/0000-0002-0189-7708
Zhong DaiNational Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China.
Jing DongShimadzu China Innovation Center, Beijing, 100020, China.
Xiaofei JiaWaters Corporation, Beijing, 100176, China.
Xuexin YangWaters Corporation, Beijing, 100176, China.
Lingwen YaoNational Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China. 184521261@qq.com.
Shuang-Cheng MaNational Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China. masc@nifdc.org.cn.
National Medical Products Administration · CNWaters (China) · CNShimadzu (China) · CN

Funding

National Natural Science Foundation of China 81303194
6 · The paper itself

Abstract

Mass spectrometry imaging is a frontier technique which connects classical mass spectrometry with ion imaging. Various types of chemicals could be visualized in their native tissues using mass spectrometry imaging. Up to now, the most commonly applied mass spectrometry imaging techniques are matrix assisted laser desorption ionization mass spectrometry imaging, desorption electrospray ionization mass spectrometry imaging and secondary ion mass spectrometry imaging. This review gives an introduction to the principles, development and applications of commonly applied mass spectrometry imaging techniques, and then illustrates the application of mass spectrometry imaging in the investigation of traditional Chinese medicine. Recently, mass spectrometry imaging has been adopted to explore the spatial distribution of endogenous metabolites in traditional Chinese medicine. Data collected from mass spectrometry imaging can be further utilized to search for marker components of traditional Chinese medicine, discover new compounds from traditional herbs, and differentiate between medicinal plants that are similar in botanical features. Moreover, mass spectrometry imaging also plays a role in revealing the pharmacological and toxicological mechanisms of traditional Chinese medicine.

Indexed as

Mass spectrometry imagingMedicinal plantsNatural compoundsSpatial distributionTraditional Chinese medicine

Identifiers

PMID35248086
PMCPMC8898510
OpenAlexW4220859211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.