Evidence map›Paper›PMID 35249015›Full record

ArticleBlood purification2022

A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood.

Young Lee, Sarah M L Steinbach, David Basile, Jaipal Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood purification, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Young LeeIndiana Center for Biomedical Innovation, Indianapolis, Indiana, USA, ylee2@iuhealth.org.
Sarah M L SteinbachDepartment of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA.
David BasileDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jaipal SinghIndiana Center for Biomedical Innovation, Indianapolis, Indiana, USA.
Indiana Department of Natural Resources · USIndiana University Health · USIndiana University School of MedicinePurdue University West Lafayette · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Preclinical Development of a Novel Disease Modifying Therapy for Pulmonary Arterial HypertensionR33HL154135 · NHLBI · VASCULONICS, LLC · PI SINGH, JAIPAL · 2020 to 2021
$832k
NCATS NIH HHS UL1 TR001108NHLBI NIH HHS R33 HL154135
6 · The paper itself

Abstract

introductionBlood levels of uremic toxin, asymmetric dimethylarginine (ADMA), are strongly associated with mortality in sepsis, renal failure, and cardiovascular and renal disease patients.

methodsAn extracorporeal approach to reduce pathological ADMA was developed. The dimethylarginine dimethylaminohydrolase (DDAH) was immobilized on agarose beads to prepare a cartridge. The efficacy of cartridge for ADMA lowering in blood was investigated.

resultsThe DDAH beads and cartridge reduced ADMA from solution or plasma. The magnitude of ADMA removal was dependent on the quantity of DDAH linked to the beads and the flow rate. When tested in association with plasmapheresis, the DDAH-cartridge was highly effective in ADMA removal from the blood and improved the arginine/ADMA ratio in a pig model.

conclusionA new, safe, and effective extracorporeal approach to lower ADMA was developed which may have application in improving outcomes in patients with vascular complications and risk of mortality associated with high ADMA.

Indexed as

ArginineKidney DiseasesAnimalsSwineArginineN,N-dimethylarginineAsymmetric dimethylarginineExtracorporeal deviceUremic toxin

Identifiers

PMID35249015
PMCPMC9440949
OpenAlexW4220652498

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.