ArticleFrontiers in immunology2022
Exploring the Ecological Implications of Microbiota Diversity in Birds: Natural Barriers Against Avian Malaria.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Microbiota-immune crosstalk in livestock: implications for tick-borne disease control.Frontiers in immunology · 2026Review
- Microbial community composition variation in relation to malaria infections in Junco hyemalis.PloS one · 2026Article
- Metagenomic analysis of the gut microbiota inFrontiers in microbiology · 2026Article
- Microbiome-Immune Interaction and Harnessing for Next-Generation Vaccines Against Highly Pathogenic Avian Influenza in Poultry.Vaccines · 2025Review
- Microbial DNA extraction method for avian feces and preen oil from diverse species.Ecology and evolution · 2024Article
- Impact ofPathogens (Basel, Switzerland) · 2024Article
- Similarities and differences: species and diet impact gut microbiota of captive pheasants.PeerJ · 2024Article
- Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries.Microorganisms · 2023Article
- A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.Frontiers in immunology · 2022Article
- Assessment of the Safety and Efficacy of an Oral Probiotic-Based Vaccine Against Aspergillus Infection in Captive-Bred Humboldt Penguins (Frontiers in immunology · 2022Article
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Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural antibodies (Abs), produced in response to bacterial gut microbiota, drive resistance to infection in vertebrates. In natural systems, gut microbiota diversity is expected to shape the spectrum of natural Abs and resistance to parasites. This hypothesis has not been empirically tested. In this 'Hypothesis and Theory' paper, we propose that enteric microbiota diversity shapes the immune response to the carbohydrate α-Gal and resistance to avian malaria. We further propose that anti-α-Gal Abs are transmitted from mother to eggs for early malaria protection in chicks. Microbiota modulation by anti-α-Gal Abs is also proposed as a mechanism favoring the early colonization of bacterial taxa with α1,3-galactosyltransferase (α1,3GT) activity in the bird gut. Our preliminary data shows that bacterial α1,3GT genes are widely distributed in the gut microbiome of wild and domestic birds. We also showed that experimental infection with the avian malaria parasite
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