Evidence map›Paper›PMID 35250998›Full record

ArticleFrontiers in immunology2022

Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation.

Benjamin G Korte, Morgan A Giese, Gayathri Ramakrishnan, Stella Ma, David Bennin, Julie Rindy, Colin N Dewey, Anna Huttenlocher

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Benjamin G KorteDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
Morgan A GieseDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
Gayathri RamakrishnanDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
Stella MaDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
David BenninDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
Julie RindyDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
Colin N DeweyDepartment of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI, United States.
Anna HuttenlocherDepartment of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, United States.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Training in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4M
ADHESIVE REGULATION DURING CELL MIGRATIONR01CA085862 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2000 to 2026
$7.3M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA085862NCI NIH HHS T32 CA009135NIAID NIH HHS T32 AI055397
6 · The paper itself

Abstract

Neutrophils in the tumor microenvironment exhibit altered functions. However, the changes in neutrophil behavior during tumor initiation remain unclear. Here we used Translating Ribosomal Affinity Purification (TRAP) and RNA sequencing to identify neutrophil, macrophage and transformed epithelial cell transcriptional changes induced by oncogenic Ras

Indexed as

ZebrafishZebrafish ProteinsAnimalsCell Transformation, NeoplasticGene Expression ProfilingLarvaThioredoxinsTumor MicroenvironmentThioredoxinsZebrafish Proteinsgene expressionkeratinocytemigrationneutrophilthioredoxin (txn)tumor initiation

Identifiers

PMID35250998
PMCPMC8891495
OpenAlexW4213103082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.