Evidence map›Paper›PMID 35253368›Full record

ArticleMolecular oncology2022

Co-occurrence of CDKN2A/B and IFN-I homozygous deletions correlates with an immunosuppressive phenotype and poor prognosis in lung adenocarcinoma.

Yuan Peng, Yonghong Chen, Mengmeng Song, Xiaoyue Zhang, Pansong Li, Xian Yu, Yusheng Huang, Ni Zhang, Liyan Ji, Lei Xia and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Hyperprogressive disease in carcinoma induced by immune checkpoint inhibitor therapy: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Pooled it
  2. Review
  3. Review
  4. Review
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  7. Review
  8. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  9. CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma.Journal of experimental & clinical cancer research : CR · 2025
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yuan PengDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yonghong ChenDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Mengmeng SongGeneplus-Beijing Institute, Beijing, China.ORCID 0000-0003-3820-2540
Xiaoyue ZhangDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Pansong LiGeneplus-Beijing Institute, Beijing, China.ORCID 0000-0002-6278-5179
Xian YuDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yusheng HuangDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ni ZhangDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Liyan JiGeneplus-Beijing Institute, Beijing, China.
Lei XiaDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Xuefeng XiaGeneplus-Beijing Institute, Beijing, China.
Xin YiGeneplus-Beijing Institute, Beijing, China.
Benxu TanDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zhenzhou YangDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homozygous deletion (HD) of CDKN2A and CDKN2B (CDKN2A/B

Indexed as

Adenocarcinoma of LungLung NeoplasmsCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16HomozygoteHumansInterferon Type IPhenotypeSequence DeletionTumor MicroenvironmentCDKN2A protein, humanCDKN2B protein, humanCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Interferon Type ICDKN2A/Bhomozygous deletiontumor immune microenvironmenttype I interferons

Identifiers

PMID35253368
PMCPMC9019898
OpenAlexW4220760095

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.