Evidence map›Paper›PMID 35253549›Full record

ReviewTechnology in cancer research & treatment

Nanocarriers Call the Last Shot in the Treatment of Brain Cancers.

Amin Mehrabian, Mohammad Mashreghi, Saba Dadpour, Ali Badiee, Leila Arabi, Seyedeh Hoda Alavizadeh, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari

Open access · goldAbstract readReview
In one paragraph

Review in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Amin MehrabianSchool of Pharmacy, Biotechnology Research Center, 37552Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-8879-7565
Mohammad MashreghiSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Saba DadpourSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Ali BadieeSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Leila ArabiSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Seyedeh Hoda AlavizadehSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Seyedeh Alia MoosavianSchool of Pharmacy, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Mahmoud Reza JaafariSchool of Pharmacy, Biotechnology Research Center, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our brain is protected by physio-biological barriers. The blood-brain barrier (BBB) main mechanism of protection relates to the abundance of tight junctions (TJs) and efflux pumps. Although BBB is crucial for healthy brain protection against toxins, it also leads to failure in a devastating disease like brain cancer. Recently, nanocarriers have been shown to pass through the BBB and improve patients' survival rates, thus becoming promising treatment strategies. Among nanocarriers, inorganic nanocarriers, solid lipid nanoparticles, liposomes, polymers, micelles, and dendrimers have reached clinical trials after delivering promising results in preclinical investigations. The size of these nanocarriers is between 10 and 1000

Indexed as

Brain NeoplasmsNanoparticlesBrainDrug Delivery SystemsHumansLiposomesLipid NanoparticlesLiposomesblood–brain barrierbrain cancerbrain drug deliverynanocarriernanomedicine

Identifiers

PMID35253549
PMCPMC8905056
OpenAlexW4221098845

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.