Evidence map›Paper›PMID 35256276›Full record

ReviewTrends in immunology2022

Guillain-Barré syndrome: expanding the concept of molecular mimicry.

Jon D Laman, Ruth Huizinga, Geert-Jan Boons, Bart C Jacobs

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06615622 (A Comparative Study of Peripheral Nerve Ultrasound Findings in Immune Mediated Peripheral Nerve Disorders; a Hospital-based Study), which is not on this map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06615622 recruitingnot on this mapstarted 2024, after this paper: background citation

A Comparative Study of Peripheral Nerve Ultrasound Findings in Immune Mediated Peripheral Nerve Disorders; a Hospital-based Study

Typeobservational_patient_registrySponsorAssiut UniversityRan2024 to 2028Enrolled90ConditionsGuillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Peripheral Nerve Disorder, Peripheral Nerves USArmsPlacebo
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The crosstalk between iron metabolism and immune tolerance in autoimmunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Guillain-Barré syndrome.BJA education · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jon D LamanDepartment of Pathology and Medical Biology, University of Groningen, UMC Groningen and MS Center Northern Netherlands (MSCNN), Groningen, The Netherlands. Electronic address: j.d.laman@umcg.nl.
Ruth HuizingaDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Geert-Jan BoonsComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712, USA; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 Utrecht, The Netherlands; Bijvoet Center for Biomolecular Research, Utrecht University, 3584 Utrecht, The Netherlands; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.
Bart C JacobsDepartment of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: b.jacobs@erasmusmc.nl.
Erasmus MC · NLUniversity Medical Center Groningen · NLUniversity of Georgia · US

Funding

Streamlining the chemoenzymatic synthesis of asymmetrical glycans of biological importanceU01GM120408 · NIGMS · UNIVERSITY OF GEORGIA · PI BOONS, GEERT-JAN · 2016 to 2019
$3.0M
NIGMS NIH HHS U01 GM120408
6 · The paper itself

Abstract

Guillain-Barré syndrome (GBS) is a rapidly progressive, monophasic, and potentially devastating immune-mediated neuropathy in humans. Preceding infections trigger the production of cross-reactive antibodies against gangliosides concentrated in human peripheral nerves. GBS is elicited by at least five distinct common bacterial and viral pathogens, speaking to the notion of polymicrobial disease causation. This opinion emphasizes that GBS is the best-supported example of true molecular mimicry at the B cell level. Moreover, we argue that mechanistically, single and multiplexed microbial carbohydrate epitopes induce IgM, IgA, and IgG subclasses in ways that challenge the classic concept of thymus-dependent (TD) versus thymus-independent (TI) antibody responses in GBS. Finally, we discuss how GBS can be exemplary for driving innovation in diagnostics and immunotherapy for other antibody-driven neurological diseases.

Indexed as

Guillain-Barre SyndromeMolecular MimicryAntibody FormationAutoantibodiesGangliosidesHumansImmunoglobulin GAutoantibodiesGangliosidesImmunoglobulin G

Identifiers

PMID35256276
PMCPMC9016725
OpenAlexW4214951143

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.