Evidence map›Paper›PMID 35256308›Full record

ArticleDisability and health journal2022

Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.

Sigan L Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M Ances, Michael A Yassa, Adam M Brickman, Benjamin L Handen, Elizabeth Head, Mark Mapstone and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disability and health journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Caregiving for Adults With Down Syndrome: Caregiver Experiences and Support Needs.Journal of applied research in intellectual disabilities : JARID · 2025
    Article
  4. Article
  5. Proxy Responses in Research on COVID-19 Among People With Intellectual and Developmental Disabilities.American journal on intellectual and developmental disabilities · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sigan L HartleyWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53706, USA; School of Human Ecology, University of Wisconsin-Madison, 1300 Linden Dr, Madison, WI 53706, USA. Electronic address: slhartley@wisc.edu.
Victoria FlemingWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53706, USA; School of Human Ecology, University of Wisconsin-Madison, 1300 Linden Dr, Madison, WI 53706, USA.
Brianna Piro-GambettiWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53706, USA; School of Human Ecology, University of Wisconsin-Madison, 1300 Linden Dr, Madison, WI 53706, USA.
Annie CohenUniversity of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Beau M AncesWashington University St. Louis, Department of Neurology, 660 Euclid Ave, St. Louis, MO 631100, USA.
Michael A YassaUniversity of California, Irvine, Neurobiology and Behavior, 213 Qureshey Research Lab, Irvine, CA 92697, USA.
Adam M BrickmanColumbia University, Department of Neurology, 710 W 168th Street, New York, NY 10033, USA.
Benjamin L HandenUniversity of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Elizabeth HeadUniveristy of California, Irvine, Department of Pathology and Laboratory medicine, 1111Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA.
Mark MapstoneUniversity of California, Irvine, Clinical Neurology, 839 Health Sciences road, Irvine, CA, 92697, USA.
Bradley T ChristianWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53706, USA.
Ira T LottUniversity of California, Irvine, Department of Psychiatry and Human Behavior, Irvine, CA 92697, USA.
Eric DoranUniversity of California Irvine, Department of Pediatrics, Bldg 2 34d Floor Rt81, 101 The City Drive, Orange, CA 92668, USA.
Shahid ZamanCambridge Intellectual & Developmental Disabilities Research Group (CIDDRG), University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Box 189, Level E4, Hills Road, Cambridge, CB2 0QQ, UK; Cambridgeshire & Peterborough NHS Foundation Trust (CPFT), Elizabeth House, Fulbourn Hospital, Cambridge Road, Cambridge, CB21 5EF, UK.
Sharon Krinsky-McHaleNew York Institute for Basic Research in Developmental Disabilities, Department of Psychology, 1050 Forest Hill Rd, Staten Island, NY 10314, USA.
Fredrick A SchmittUniversity of Kentucky, Department of Neurosurgery, 740 S. Limestone, Lexington, KY 40536, USA.
Christy HomUniversity of California Irvine, Department of Pediatrics, Bldg 2 34d Floor Rt81, 101 The City Drive, Orange, CA 92668, USA.
Nicole SchupfColumbia University, Department of Neurology, 710 W 168th Street, New York, NY 10033, USA.
ABC-DS Group

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$18.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · UNIVERSITY OF CALIFORNIA-IRVINE · 2025 to 2025
$4.3M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · UNIVERSITY OF KENTUCKY · 2025 to 2025
$2.8M
NCATS NIH HHS UL1 TR001414NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG070028NIA NIH HHS T32 AG057461NIA NIH HHS U01 AG051406NIA NIH HHS U01 AG051412NIA NIH HHS U19 AG068054NICHD NIH HHS R01 HD064993NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

backgroundThe Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread of COVID-19 may also have taken a heavy toll on the daily lives of individuals with Down syndrome. OBJECTIVE/HYPOTHESIS: The goal of the study was to understand how the COVID-19 pandemic has altered daily life (including residence, employment, and participation in adult disability day programs) and influenced the mood and behavior of adults with Down syndrome.

methodsBetween September 2020 and February 2021, caregivers of 171 adults with Down syndrome (aged 22-66 years) located across the United States and in the United Kingdom enrolled in the Alzheimer's Biomarker Research Consortium on Down Syndrome (ABC-DS) completed a survey.

resultsThe residence of 17% of individuals was altered, and 89% of those who had been employed stopped working during the pandemic. One-third (33%) of individuals were reported to be more irritable or easily angered, 52% were reported to be more anxious, and 41% were reported to be more sad/depressed/unhappy relative to prepandemic. The majority of changes in mood and behavior were of modest severity.

conclusionsThe COVID-19 pandemic has had widespread effects on the daily life and mood and behavior of adults with Down syndrome. In the short term, caregivers and providers should be prepared to help adults with Down syndrome with changes in daily routines, residence, employment, or adult disability day programs as society shifts away from COVID-19 safety protocols.

Indexed as

COVID-19Down SyndromePersons with DisabilitiesAdultAffectHumansPandemicsUnited StatesCoronavirusCOVID-19Daily lifeDown syndromeMoodPandemic

Identifiers

PMID35256308
PMCPMC8849846

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.