ArticleNeurology2022
Autopsy Validation of the Diagnostic Accuracy of
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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Who cites it
32 citing papers in PubMed, 41 citations in OpenAlex.
- Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies.Japanese journal of radiology · 2026Review
- Progression to Dementia in Very Late-Onset Schizophrenia-Like Psychosis Stratified by Alzheimer's Disease and Lewy Body Disease Biomarkers: A Retrospective Cohort Study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Brain-first and body-first subtypes of Lewy body disease.Nature reviews. Neurology · 2026Review
- Neuropathological correlates of imaging in dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Cardiac 123I-Meta-Iodobenzylguanidine Imaging as a Biomarker for Body-First Parkinson's Disease: Linking Peripheral α-Synuclein to Clinical Subtyping.Journal of movement disorders · 2026Article
- Heterogeneity of dementia with lewy bodies: Insights from clinical presentations, neuropathology, and biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies.Molecular neurodegeneration · 2025Review
- Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein.Molecular neurodegeneration · 2025Review
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- Myocardial sympathetic distal axon loss in subjects with Lewy pathology in three autopsy cohorts.Acta neuropathologica · 2025Article
- Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies.Psychological medicine · 2025Article
- The Heart of the Matter: Cardiac Denervation Casts Doubt on the Brain-First Versus Body-First Hypothesis of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Impact of selegiline onOxford medical case reports · 2025Article
- Value of multi-parameterEJNMMI research · 2025Article
- Non-coding repeat analyses in patients with Parkinson's disease.Frontiers in neurology · 2025Article
- Correlation analyses between MIBG myocardial scintigraphy and monoamine levels in dementia with Lewy bodies show potential link with the serotonergic system.Clinical parkinsonism & related disorders · 2025Article
- Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism.Brain communications · 2025Article
- Iodine-123 Metaiodobenzylguanidine (I-123 MIBG) in Clinical Applications: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease.NPJ Parkinson's disease · 2024Article
- Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients.Scientific data · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Tomoyasu MatsubaraFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0002-7559-8284
Masashi KameyamaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0001-9496-2590
Noriko TanakaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0003-3025-1591
Renpei SengokuFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0002-3325-853X
Makoto OritaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.
Ko FurutaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.
Atsushi IwataFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0001-7308-5314
Tomio AraiFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0003-4583-8301
Hirofumi MaruyamaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0001-7613-8717
Yuko SaitoFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.
Shigeo MurayamaFrom the Department of Neuropathology (Brain Bank for Aging Research) (T.M., M.O., Y.S., S.M.), Department of Diagnostic Radiology (M.K.), Health Data Science Research Section (N.T.), Healthy Aging Innovation Center, Department of Neurology (R.S., A.I., S.M.), Department of Pathology (M.O., T.A.), and Department of Psychiatry (K.F.), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology; Department of Clinical Neuroscience and Therapeutics (T.M., H.M.), Hiroshima University Graduate School of Biomedical and Health Sciences; and Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (S.M.), United Graduate School of Child Development, Osaka University, Japan.ORCID 0000-0001-9709-5242
Tokyo Metropolitan Institute of Gerontology · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectives
methodsThis retrospective, cross-sectional study included consecutive autopsy patients from the Brain Bank for Aging Research who had undergone
resultsWe analyzed the data of 56 patients (30 with pathologically confirmed LBDs and 26 without LBD pathology). Compared with the neuropathologic diagnosis, the early heart-to-mediastinum (H/M) ratio had a sensitivity and specificity of 70.0% (95% CI 50.6%-85.3%) and 96.2% (95% CI 80.4%-99.9%), respectively. The delayed H/M ratio had a sensitivity and specificity of 80.0% (95% CI 61.4%-92.3%) and 92.3% (95% CI 74.9%-99.1%), respectively. The washout rate had a sensitivity and specificity of 80.0% (95% CI 61.4%-92.3%) and 84.6% (95% CI 65.1%-95.6%), respectively. The proportion of residual TH-immunoreactive cardiac sympathetic fibers strongly correlated with the amount of cardiac DISCUSSION: This clinicopathologic validation study revealed that CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that
Indexed as
3-IodobenzylguanidineLewy Body DiseaseMyocardial Perfusion ImagingAutopsyCross-Sectional StudiesHeartHumansIodine RadioisotopesRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesTyrosine 3-Monooxygenase3-IodobenzylguanidineIodine-123Iodine RadioisotopesRadiopharmaceuticalsTyrosine 3-Monooxygenase
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