Evidence map›Paper›PMID 35256948›Full record

ArticleActa pharmaceutica Sinica. B2022

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice.

Mallory Little, Moumita Dutta, Hao Li, Adam Matson, Xiaojian Shi, Gabby Mascarinas, Bruk Molla, Kris Weigel, Haiwei Gu, Sridhar Mani and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Mallory LittleDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Moumita DuttaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Hao LiDepartment of Medicine, Molecular Pharmacology and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Adam MatsonUniversity of Connecticut, Hartford, CT 06106, USA.
Xiaojian ShiArizona Metabolomics Laboratory, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Gabby MascarinasDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Bruk MollaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Kris WeigelDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Haiwei GuArizona Metabolomics Laboratory, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Sridhar ManiDepartment of Medicine, Molecular Pharmacology and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Julia Yue CuiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
University of Washington · USAlbert Einstein College of Medicine · USArizona State University · USUniversity of Connecticut · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
TISSUE FACTOR IN BLOOD COAGULATIONP01HL029019 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI NEMERSON, YALE R · 1985 to 2002
$5.8M
Developmental PBDE exposure, gut microbiome, and diabetesR01ES030197 · NIEHS · UNIVERSITY OF WASHINGTON · PI Julia Yue Cui, Haiwei Gu · 2019 to 2026
$5.0M
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?R01ES031098 · NIEHS · UNIVERSITY OF IOWA · PI CUI, JULIA YUE, LEHMLER, HANS-JOACHIM · 2020 to 2024
$3.1M
MOLECULAR DISSECTION OF CALMODULIN DOMAIN INTERACTIONSR01GM057001 · NIGMS · UNIVERSITY OF IOWA · PI SHEA, MADELINE A · 1998 to 2015
$2.9M
Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal CancerR01CA222469 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MANI, SRIDHAR · 2018 to 2022
$2.3M
Epigenetic Regulation of Drug Metabolism by Developmental Exposure to PBDEsR01ES025708 · NIEHS · UNIVERSITY OF WASHINGTON · PI CUI, JULIA YUE · 2015 to 2019
$1.7M
Developmental Regulation of Drug Metabolism by Targeting the Gut MicrobiomeR01GM111381 · NIGMS · UNIVERSITY OF WASHINGTON · PI CUI, JULIA YUE · 2014 to 2018
$1.5M
Supporting Undergraduate Research Experiences in Environmental Health (SURE-EH)R25ES025503 · NIEHS · UNIVERSITY OF WASHINGTON · PI Karen Levy · 2015 to 2026
$1.3M
NCI NIH HHS R01 CA222469NHLBI NIH HHS P01 HL029019NICHD NIH HHS P50 HD103524NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES025708NIEHS NIH HHS R01 ES030197NIEHS NIH HHS R01 ES031098NIEHS NIH HHS R25 ES025503NIGMS NIH HHS R01 GM057001NIGMS NIH HHS R01 GM111381
6 · The paper itself

Abstract

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of

Indexed as

BA, bile acidBile acidsBSH, bile salt hydrolaseCA, cholic acidCARCAR, constitutive androstane receptorCDCA, chenodeoxycholic acidCITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximeCV, conventionalCYP, cytochrome P450DCA, deoxycholic acidEGF, epidermal growth factorFecesGF, germ freeGLP-1, glucagon-like peptide-1GM-CSF, granulocyte-macrophage colony-stimulating factorGut microbiomeHDCA, hyodeoxycholic acidhPXR-TG, humanized PXR transgenicIBD, inflammatory bowel diseaseIFNγ, interferon-gammaIL, interleukinInflammationIS, internal standardsLCA, lithocholic acidLC–MS/MS, liquid chromatography–tandem mass spectrometryMCA, muricholic acidMCP-1, monocyte chemoattractant protein-1MiceNF-κB, nuclear factor kappa-light-chain-enhancer of activated B cellsNSAID, non-steroidal anti-inflammatory drugNuclear receptorOH, hydroxylatedOTUs, operational taxonomy unitsPA, indole-3 propionic acidPBDEs, polybrominated diphenyl ethersPCBs, polychlorinated biphenylsPCoA, Principle Coordinate AnalysisPiCRUSt, Phylogenetic Investigation of Communities by Reconstruction of Observed StatesPXRPXR, pregnane X receptorQIIME, Quantitative Insights Into Microbial EcologySCFAs, short-chain fatty acidsSNP, single-nucleotide polymorphismSPF, specific-pathogen-freeTCPOBOP, 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzeneTGR-5, Takeda G-protein-coupled receptor 5TLR4, toll-like receptor 4TNF, tumor necrosis factorT-, taurine conjugatedT, wild typeUDCA, ursodeoxycholic acidYAP, yes-associated protein

Identifiers

PMID35256948
PMCPMC8897037
OpenAlexW3120011788

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.